PMID- 25535146
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 18
IP  - 23
DP  - 2014
TI  - alpha-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute 
      cerebral infarction.
PG  - 3715-9
LID - 8177 [pii]
AB  - OBJECTIVE: This study aims to evaluate the efficacy and safety of alpha-lipoic acid 
      in the treatment of aged type 2 diabetes mellitus (T2DM) complicated with acute 
      cerebral infarction. PATIENTS AND METHODS: 90 patients were randomly divided into 
      two groups, on the basis of conventional treatment. The experiment group was 
      administrated with alpha-lipoic acid, while only Vitamin C for the control group, for 
      3 consecutive weeks. Before and after the experiment, superoxide dismutase (SOD), 
      glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels were measured 
      and scored with the NIHSS (National Institutes of Health Stroke Scale), and the 
      changes of blood glucose, insulin function and other indicators were observed. 
      RESULTS: After the treatment, the plasma SOD and GSH-Px levels increased, while 
      MDA decreased (p < 0.05), with statistical significance when compared with the 
      control group (p < 0.01). NIHSS score, blood glucose, blood lipids and HOMA-IA of 
      the experiment group decreased significantly (p < 0.01); and no significant 
      adverse reactions were found in both groups. CONCLUSIONS: alpha-lipoic acid was safe 
      and effective in the treatment of aged T2DM complicated with acute cerebral 
      infarction, significantly reducing the patient's oxidative stress, blood glucose 
      and lipid levels and being able to improve islet function.
FAU - Zhao, L
AU  - Zhao L
AD  - Department of Endocrinology, Hedong District People's Hospital, Linyi, China. 
      liangzhaocn@126.com.
FAU - Hu, F-X
AU  - Hu FX
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aging/blood/*drug effects/pathology
MH  - Antioxidants/pharmacology/*therapeutic use
MH  - Ascorbic Acid/pharmacology/therapeutic use
MH  - Blood Glucose/drug effects/metabolism
MH  - Cerebral Infarction/blood/complications/*drug therapy
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/drug effects/physiology
MH  - Thioctic Acid/pharmacology/*therapeutic use
MH  - Treatment Outcome
EDAT- 2014/12/24 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - 8177 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2014;18(23):3715-9.