PMID- 25535475
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141223
LR  - 20200930
IS  - 1226-8453 (Print)
IS  - 2093-4947 (Electronic)
IS  - 1226-8453 (Linking)
VI  - 39
IP  - 1
DP  - 2015 Jan
TI  - Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of 
      OVA-induced asthma model in mice.
PG  - 38-45
LID - 10.1016/j.jgr.2014.07.004 [doi]
AB  - BACKGROUND: Korean ginseng is a well-known medicinal herb that has been widely 
      used in traditional medicine to treat various diseases, including asthma. Ginseng 
      can be classified as white ginseng (WG) or red ginseng (RG), according to 
      processing conditions. In this study, the authors compared the efficacies of 
      these two ginseng types in a mouse model of acute asthma. METHODS: To produce the 
      acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum 
      hydroxide, and then challenged with OVA. WG and RG extracts were administered to 
      mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), 
      immune cell distributions in bronchoalveolar lavage fluid (BALF), and 
      OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. 
      Cytokine production by lymphocytes isolated from peribronchial lymph nodes and 
      histopathological changes was also examined. RESULTS: In OVA-sensitized mice, 
      both WG and RG reduced AHR and suppressed immune cell infiltration in 
      bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in 
      RG-treated OVA-sensitized mice than in the OVA-sensitized control group. WG and 
      RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. 
      Histopathological findings showed reduced inflammatory cell infiltration and 
      airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice 
      compared with OVA controls. CONCLUSION: In this study, WG and RG showed 
      antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG 
      were found to be better than those of WG.
FAU - Lim, Chi-Yeon
AU  - Lim CY
AD  - College of Medicine, Dongguk University, Ilsan, Gyeonggi-do, Korea.
FAU - Moon, Jeong-Min
AU  - Moon JM
AD  - School of Korean Medicine, Pusan National University, Yangsan, Korea.
FAU - Kim, Bu-Yeo
AU  - Kim BY
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 
      Korea.
FAU - Lim, Se-Hyun
AU  - Lim SH
AD  - School of Public Health, Far East University, Chungbuk, Korea.
FAU - Lee, Guem-San
AU  - Lee GS
AD  - College of Korean Medicine, Wonkwang University, Iksan, Jeonbuk, Korea.
FAU - Yu, Hak-Sun
AU  - Yu HS
AD  - Department of Parasitology, School of Medicine, Pusan National University, 
      Yangsan, Korea.
FAU - Cho, Su-In
AU  - Cho SI
AD  - School of Korean Medicine, Pusan National University, Yangsan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140801
PL  - Korea (South)
TA  - J Ginseng Res
JT  - Journal of ginseng research
JID - 100890690
PMC - PMC4268570
OTO - NOTNLM
OT  - Korean ginseng
OT  - asthma
OT  - red ginseng
OT  - white ginseng
EDAT- 2014/12/24 06:00
MHDA- 2014/12/24 06:01
PMCR- 2014/08/01
CRDT- 2014/12/24 06:00
PHST- 2014/04/23 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2014/12/24 06:01 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S1226-8453(14)00087-6 [pii]
AID - 10.1016/j.jgr.2014.07.004 [doi]
PST - ppublish
SO  - J Ginseng Res. 2015 Jan;39(1):38-45. doi: 10.1016/j.jgr.2014.07.004. Epub 2014 
      Aug 1.