PMID- 25535750
OWN - NLM
STAT- MEDLINE
DCOM- 20150430
LR  - 20220408
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 33
IP  - 1
DP  - 2015 Jan-Feb
TI  - Diabetes mellitus risk factors in rheumatoid arthritis: a systematic review and 
      meta-analysis.
PG  - 115-21
AB  - OBJECTIVES: The aim of this study was to investigate the relationship between 
      rheumatoid arthritis (RA) and the occurrence of diabetes mellitus (DM). METHODS: 
      A meta-analysis was conducted to explore the risk of DM in RA patients. All 
      relevant studies were identified by searching PUBMED, EMBASE and MEDLINE database 
      prior to 1 January 2014. Pooled risk estimates were calculated with 
      random-effects models using STATA 11.0. RESULTS: A total of 11 case-control 
      studies and 8 cohort studies were included in the final analysis. The pooled risk 
      estimate of 11 case-control studies showed a statistically significant increased 
      risk of DM prevalence among RA individuals (OR=1.40, 95% CI: 1.34-1.47). The 
      pooled risk estimate of 8 cohort studies also showed a statistically significant 
      increasing risk of DM (RR=1.43, 95%CI: 1.38-1.47). In a subgroup analysis for 
      case-control studies, the pooled risk estimate of individuals with RA increased 
      the incidence of T1DM (type 1 diabetes mellitus) and the incidence of T2DM (type 
      2 diabetes mellitus) (OR, 4.78 vs. 1.41). In a subgroup analysis for cohort 
      studies, RA was also found to have a statistically significant increasing risk of 
      T2DM (RR=1.24, 95%CI: 1.14-1.35). Begg funnel plot and Egger test showed no 
      evidence of publication bias. CONCLUSIONS: RA is associated with increased risk 
      of DM, including T1DM and T2DM.
FAU - Jiang, Ping
AU  - Jiang P
AD  - Shandong University of Tranditional Chinese Medicine, Jinan, China.
FAU - Li, Hao
AU  - Li H
AD  - Department of Surgery, Shanghai Jiao Tong University Affiliated First People's 
      Hospital, Shanghai, China.
FAU - Li, Xiao
AU  - Li X
AD  - The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 
      Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20141222
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Arthritis, Rheumatoid/diagnosis/*epidemiology
MH  - Diabetes Mellitus, Type 1/diagnosis/*epidemiology
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Odds Ratio
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2014/12/24 06:00
MHDA- 2015/05/01 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/04/13 00:00 [received]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/05/01 06:00 [medline]
AID - 8171 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2015 Jan-Feb;33(1):115-21. Epub 2014 Dec 22.