PMID- 25536373
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 123
IP  - 5
DP  - 2015 May
TI  - Association between lung function in adults and plasma DDT and DDE levels: 
      results from the Canadian Health Measures Survey.
PG  - 422-7
LID - 10.1289/ehp.1408217 [doi]
AB  - BACKGROUND: Although DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane] has been 
      banned in many countries since the 1970s, it may still pose a risk to human 
      respiratory health. In agriculture, DDT exposures have been associated with 
      asthma and chronic bronchitis. However, little is known about the effect of DDT 
      on lung function. METHODS: We used data on 1,696 participants 20-79 years of age 
      from the Canadian Health Measures Survey (CHMS) and conducted multiple regression 
      analysis to estimate associations between plasma p,p -DDT/DDE and lung function. 
      RESULTS: Almost all participants (> 99.0%) had detectable concentrations of 
      plasma p,p -DDE, but only 10.0% had detectable p,p -DDT. Participants with 
      detectable p,p -DDT had significantly lower mean FVC (difference = 311 mL; 95% 
      CI: -492, -130; p = 0.003) and FEV1 (difference = 232 mL; 95% CI: -408, -55; p = 
      0.015) than those without. A 100-ng/g lipid increase in plasma p,p -DDE was 
      associated with an 18.8-mL decrease in mean FVC (95% CI: -29, -9) and an 11.8-mL 
      decrease in mean FEV1 (95% CI: -21, -3). Neither exposure was associated with 
      FEV1/FVC ratio or FEF25%-75%. CONCLUSIONS: DDT exposures, which may have occurred 
      decades ago, were still detectable among Canadians. Plasma DDT and DDE were 
      negatively associated with lung function parameters. Additional research on the 
      potential effects of DDT use on lung function is warranted.
FAU - Ye, Ming
AU  - Ye M
AD  - School of Public Health.
FAU - Beach, Jeremy
AU  - Beach J
FAU - Martin, Jonathan W
AU  - Martin JW
FAU - Senthilselvan, Ambikaipakan
AU  - Senthilselvan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141223
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - CIW5S16655 (DDT)
SB  - IM
EIN - Environ Health Perspect. 2015 May;123(5):A116. PMID: 25932643
MH  - Adult
MH  - Aged
MH  - Canada
MH  - DDT/*blood
MH  - Dichlorodiphenyl Dichloroethylene/*blood
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Lung/*physiology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Respiratory Function Tests
MH  - Young Adult
PMC - PMC4420627
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2014/12/24 06:00
MHDA- 2016/02/05 06:00
PMCR- 2015/05/01
CRDT- 2014/12/24 06:00
PHST- 2014/02/03 00:00 [received]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - ehp.1408217 [pii]
AID - 10.1289/ehp.1408217 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2015 May;123(5):422-7. doi: 10.1289/ehp.1408217. Epub 
      2014 Dec 23.