PMID- 25536405
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 12
DP  - 2014
TI  - Human papillomavirus infection in 674 Chinese patients with laryngeal squamous 
      cell carcinoma.
PG  - e115914
LID - 10.1371/journal.pone.0115914 [doi]
LID - e115914
AB  - OBJECTIVES: Previous reports suggest a strong association between human 
      papillomavirus (HPV) and the etiology of laryngeal squamous cell carcinoma 
      (LSCC). However, clinical data regarding the HPV infection rate among LSCC 
      patients remain largely inconsistent. METHODS: In total, 674 LSCC patients from 
      three major hospitals in Shanghai were enrolled in this study. We determined the 
      patients' HPV infection status using immunohistochemistry and the GenoArray HPV 
      genotyping assay and calculated their long-term survival rate using the 
      Kaplan-Meier method. RESULTS: The total P16-positive rate according to 
      immunostaining results was 7.57% (51/674). None of the P16-negative patients were 
      HPV-positive according to the HPV genotyping test. The rate of HPV infection 
      among patients with LSCC was 4.9% (33/674). HPV infection was more common among 
      nonsmokers (P<0.05), nondrinkers (P<0.05), and patients with supraglottic LSCC 
      (P<0.05). Of the 33 HPV-positive patients, 28 (84.8%) were infected with HPV-16, 
      2 with HPV-18, 1 with HPV-31, 1 with HPV-33 and 1 with HPV-45. The 3-year overall 
      survival rate and progression-free survival rate were higher in HPV-positive than 
      HPV-negative patients, but the difference was not statistically significant 
      (76.3% vs. 70.7%, P = 0.30 and 65.1% vs. 58.3%, P = 0.37, respectively). 
      CONCLUSION: HPV was not a main causal factor in LSCC carcinogenesis in this 
      Chinese population. HPV infection did not alter patients' overall survival or 
      progression-free survival rates in this study.
FAU - Xu, Yanan
AU  - Xu Y
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China; Department of Head and Neck Surgery, Renji 
      Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China; 
      Otolaryngological Institute of Shanghai Jiaotong University, Shanghai, China.
FAU - Liu, Suru
AU  - Liu S
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China; Otolaryngological Institute of Shanghai 
      Jiaotong University, Shanghai, China.
FAU - Yi, Hongliang
AU  - Yi H
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China; Otolaryngological Institute of Shanghai 
      Jiaotong University, Shanghai, China.
FAU - Wang, Jiadong
AU  - Wang J
AD  - Department of Head and Neck Surgery, Renji Hospital of Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China; Otolaryngological Institute of 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Dong, Pin
AU  - Dong P
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University 
      Affiliated First People's Hospital, Shanghai, China; Otolaryngological Institute 
      of Shanghai Jiaotong University, Shanghai, China.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Otolaryngology Head and Neck Surgery, Children's Hospital 
      Affiliated to Shanghai Jiaotong University, Shanghai, China.
FAU - Yin, Shankai
AU  - Yin S
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai, China; Otolaryngological Institute of Shanghai 
      Jiaotong University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20141223
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*complications/epidemiology
MH  - China/epidemiology
MH  - Female
MH  - Human papillomavirus 16/isolation & purification
MH  - Human papillomavirus 18/isolation & purification
MH  - Human papillomavirus 31/isolation & purification
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*complications/epidemiology
MH  - Larynx/pathology
MH  - Male
MH  - Middle Aged
MH  - Papillomavirus Infections/*complications/diagnosis/epidemiology
MH  - Young Adult
PMC - PMC4275260
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/12/24 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/12/23
CRDT- 2014/12/24 06:00
PHST- 2014/09/22 00:00 [received]
PHST- 2014/11/30 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/12/23 00:00 [pmc-release]
AID - PONE-D-14-42648 [pii]
AID - 10.1371/journal.pone.0115914 [doi]
PST - epublish
SO  - PLoS One. 2014 Dec 23;9(12):e115914. doi: 10.1371/journal.pone.0115914. 
      eCollection 2014.