PMID- 25536452
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20220410
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 174
DP  - 2015 Mar 15
TI  - Frequency-dependent alterations in the amplitude of low-frequency fluctuations in 
      social anxiety disorder.
PG  - 329-35
LID - S0165-0327(14)00786-1 [pii]
LID - 10.1016/j.jad.2014.12.001 [doi]
AB  - BACKGROUND: Recent studies on resting-state functional magnetic resonance imaging 
      (fMRI) have found an abnormal temporal correlation between low-frequency 
      oscillations (LFO) in social anxiety disorder (SAD). However, alterations in the 
      amplitudes of these LFO remain unclear. METHODS: This study included 20 SAD 
      patients and 20 age-, gender-, and education-matched healthy controls. 
      Resting-state fMRI data were acquired using a gradient-echo echo-planar imaging 
      sequence, and the amplitudes of LFO were investigated using the amplitude of 
      low-frequency fluctuation (ALFF) approach. Two frequency bands (slow-5: 
      0.01-0.027Hz; slow-4: 0.027-0.073Hz) were analyzed. RESULTS: Significant 
      differences in ALFF were observed between the two bands in widespread regions 
      including the postcentral gyrus, precentral gyrus, medial prefrontal cortex 
      (MPFC), orbitofrontal cortex, hippocampus, thalamus, caudate, putamen, and 
      insula. Compared with the healthy controls, the SAD patients showed lower ALFF in 
      the dorsolateral prefrontal cortex (DLPFC), MPFC, superior temporal gyrus, and 
      insula but higher ALFF in the middle occipital gyrus. Furthermore, we found that 
      the SAD patients had reduced ALFF in the MPFC in the slow-5 band. LIMITATION: The 
      small sample size may decrease the statistical power of the results. CONCLUSIONS: 
      SAD patients had frequency-dependent alteration in intrinsic brain activity. This 
      finding may provide insights into the understanding of the pathophysiology of 
      SAD.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Zhang, Youxue
AU  - Zhang Y
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Zhu, Chunyan
AU  - Zhu C
AD  - Department of Psychiatry, West China School of Medicine, West China Hospital of 
      Sichuan University, Chengdu 610041, PR China.
FAU - Chen, Heng
AU  - Chen H
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Duan, Xujun
AU  - Duan X
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Lu, Fengmei
AU  - Lu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Li, Meiling
AU  - Li M
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Liu, Feng
AU  - Liu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Ma, Xujing
AU  - Ma X
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Wang, Yifeng
AU  - Wang Y
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Zeng, Ling
AU  - Zeng L
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Psychiatry, West China School of Medicine, West China Hospital of 
      Sichuan University, Chengdu 610041, PR China. Electronic address: 
      weizhang27@163.com.
FAU - Chen, Huafu
AU  - Chen H
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 611054, Sichuan, PR China. Electronic address: chenhf@uestc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141210
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/physiopathology
MH  - Case-Control Studies
MH  - Cerebral Cortex/*physiopathology
MH  - *Echo-Planar Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occipital Lobe/physiopathology
MH  - Phobic Disorders/*physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Temporal Lobe/physiopathology
OTO - NOTNLM
OT  - Frequency-dependent
OT  - Low-frequency fluctuation
OT  - Medial prefrontal cortex
OT  - Social anxiety disorder
EDAT- 2014/12/24 06:00
MHDA- 2015/08/19 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/11/29 00:00 [revised]
PHST- 2014/12/02 00:00 [accepted]
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - S0165-0327(14)00786-1 [pii]
AID - 10.1016/j.jad.2014.12.001 [doi]
PST - ppublish
SO  - J Affect Disord. 2015 Mar 15;174:329-35. doi: 10.1016/j.jad.2014.12.001. Epub 
      2014 Dec 10.