PMID- 25536519
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20150212
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 6
IP  - 2
DP  - 2015 Feb
TI  - Cholesterol side chain analogs but not its ether analogs possess 
      cholesterol-lowering activity.
PG  - 630-4
LID - 10.1039/c4fo01044b [doi]
AB  - Cholesterol analogs can be used to treat hypercholesterolemia. The present study 
      was to test the effects of cholesteryl 3beta-ethoxy (CE) and cholesteryl 3beta-methoxy 
      (CM) on plasma total cholesterol (TC) compared with that of beta-sitosterol (SI) in 
      hamsters fed a high cholesterol diet. CM and CE are the methoxy and ethoxy 
      analogs of cholesterol while SI is an analog of cholesterol having an additional 
      ethyl group on the side chain. Results showed that SI at a dose of 0.1% could 
      effectively reduce plasma TC by 18%. The analysis of sterols in the plasma and 
      liver did not detect the presence of SI, proving that it was poorly absorbed in 
      the intestine. In contrast, both CE and CM had no effect on plasma TC. However, 
      CE and CM were found to accumulate in both plasma and liver, indicating that they 
      could be well absorbed in the intestine. It was therefore concluded that analogs 
      having different side chains possessed plasma TC-lowering activity, while analogs 
      or derivatives on the hydroxyl group had no hypocholesterolemic activity.
FAU - Lei, Lin
AU  - Lei L
AD  - Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong, Shatin, NT, Hong Kong, China. zhenyuchen@cuhk.edu.hk.
FAU - Wang, Xiaobo
AU  - Wang X
FAU - Huang, Weihuan
AU  - Huang W
FAU - Liu, Yuwei
AU  - Liu Y
FAU - Zheng, Fangrui
AU  - Zheng F
FAU - Ma, Ka Ying
AU  - Ma KY
FAU - Li, Yuk Man
AU  - Li YM
FAU - Wang, Lijun
AU  - Wang L
FAU - Man, Sun Wa
AU  - Man SW
FAU - Zhang, Chengnan
AU  - Zhang C
FAU - Chen, Zhen-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Sitosterols)
RN  - 0 (Sterols)
RN  - 0 (cholesteryl 3beta-ethoxy)
RN  - 0 (cholesteryl 3beta-methoxy)
RN  - 5LI01C78DD (gamma-sitosterol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Anticholesteremic Agents/*pharmacology
MH  - Cholesterol/*analogs & derivatives/*blood/pharmacology
MH  - Cholesterol, Dietary/administration & dosage/adverse effects
MH  - Cricetinae
MH  - Diet, High-Fat/adverse effects
MH  - Feces/chemistry
MH  - Hypercholesterolemia/drug therapy
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Organ Size/drug effects
MH  - Sitosterols/pharmacology
MH  - Sterols/blood
EDAT- 2014/12/24 06:00
MHDA- 2016/03/02 06:00
CRDT- 2014/12/24 06:00
PHST- 2014/12/24 06:00 [entrez]
PHST- 2014/12/24 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.1039/c4fo01044b [doi]
PST - ppublish
SO  - Food Funct. 2015 Feb;6(2):630-4. doi: 10.1039/c4fo01044b.