PMID- 25537992
OWN - NLM
STAT- MEDLINE
DCOM- 20160511
LR  - 20181113
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 15
IP  - 7
DP  - 2015 Jul
TI  - Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in 
      type 2 diabetes mellitus patients?
PG  - 524-30
LID - 10.5152/akd.2014.5555 [doi]
AB  - OBJECTIVE: Diabetes mellitus is a major risk factor for cardiovascular disease 
      (CVD). We investigated the relationship among biochemical and cardiac risk 
      parameters with the methylenetetrahydrofolate reductase (MTHFR) C677T genotype in 
      type 2 diabetes mellitus (T2DM) patients. METHODS: One hundred seven T2DM 
      subjects with severe CVD diagnosed by angiography were included consecutively in 
      this cross-sectional study. Biochemical and clinical parameters were obtained 
      from patients who were not positive for nephropathy and retinopathy. MTHFR C677T 
      genotypes were analyzed using polymerase chain reaction-restriction fragment 
      length polymorphism (PCR-RFLP) methods. Normally and abnormally distributed 
      continuous variables were analyzed using student t- and Mann-Whitney U tests. 
      Categorical variables were analyzed using chi-square test. RESULTS: In the study, 
      31 T2DM subjects had the CC (29.0%), 62 had the CT (57.9%), and 14 had the TT 
      (13.1%) genotypes. There were no significant differences between subjects with 
      wild-type (677CC) and with mutant (677CT+677TT) alleles in terms of diabetes 
      duration, visceral fat area, total cholesterol, triglyceride, fasting plasma 
      glucose, systolic blood pressure, diastolic blood pressure, high-sensitivity 
      C-reactive protein, homocysteine (Hcy), and carotid intima-media thickness 
      values. CONCLUSION: This study suggests that MTHFR gene polymorphisms can not be 
      used as a marker for the assessment of cardiovascular risk in T2DM patients.
FAU - Bahadir, Anzel
AU  - Bahadir A
AD  - Department of Biophysics, Faculty of Medicine, Duzce University; Duzce-Turkey. 
      anzel78@hotmail.com.
FAU - Eroz, Recep
AU  - Eroz R
FAU - Turker, Yasin
AU  - Turker Y
LA  - eng
PT  - Journal Article
DEP - 20140502
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Cardiovascular Diseases/blood/complications/diagnostic imaging/*genetics
MH  - Coronary Angiography
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
PMC - PMC5337029
COIS- Conflict of interest: None declared.
EDAT- 2014/12/30 06:00
MHDA- 2016/05/12 06:00
PMCR- 2015/07/01
CRDT- 2014/12/25 06:00
PHST- 2014/12/25 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2016/05/12 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - AJC-15-524 [pii]
AID - 10.5152/akd.2014.5555 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2015 Jul;15(7):524-30. doi: 10.5152/akd.2014.5555. Epub 2014 
      May 2.