PMID- 2553845
OWN - NLM
STAT- MEDLINE
DCOM- 19891130
LR  - 20190903
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 226
IP  - 4
DP  - 1989 Oct
TI  - High serum erythropoietin levels are normalized during treatment of congestive 
      heart failure with enalapril.
PG  - 257-60
AB  - Eighteen patients with dilated cardiomyopathy (three female, mean age 57 years), 
      were treated for 48 weeks with enalapril added to digoxin and diuretic therapy 
      for congestive heart failure of New York Heart Association (NYHA) functional 
      class II (three patients). III (eight patients) and IV (seven patients), 
      respectively. Serum levels of erythropoietin (EPO) were raised at the start (37 
      +/- 12.8 pmol 1(-1); mean +/- SD) and were normalized during enalapril treatment 
      (17.5 +/- 9.9 pmol 1(-1) at 48 weeks; P less than 0.001). Serum EPO correlated at 
      the start with NYHA functional class (r = 0.68; P less than 0.05). Normalization 
      of elevated serum EPO concentrations during treatment with enalapril paralleled 
      clinical and haemodynamic improvement, and probably reflected relief from renal 
      hypoxia.
FAU - Fyhrquist, F
AU  - Fyhrquist F
AD  - Minerva Institute for Medical Research, Helsinki, Finland.
FAU - Karppinen, K
AU  - Karppinen K
FAU - Honkanen, T
AU  - Honkanen T
FAU - Saijonmaa, O
AU  - Saijonmaa O
FAU - Rosenlof, K
AU  - Rosenlof K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 11096-26-7 (Erythropoietin)
RN  - 69PN84IO1A (Enalapril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Enalapril/*therapeutic use
MH  - Erythropoietin/*blood
MH  - Female
MH  - Heart Failure/blood/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1989.tb01390.x [doi]
PST - ppublish
SO  - J Intern Med. 1989 Oct;226(4):257-60. doi: 10.1111/j.1365-2796.1989.tb01390.x.