PMID- 25538582
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141224
LR  - 20220310
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 8
DP  - 2014
TI  - Relationships between brain-derived neurotrophic factor, clinical symptoms, and 
      decision-making in chronic schizophrenia: data from the Iowa Gambling Task.
PG  - 417
LID - 10.3389/fnbeh.2014.00417 [doi]
LID - 417
AB  - The levels of brain-derived neurotrophic factor (BDNF) are significantly 
      decreased in patients with schizophrenia and correlate with impairments in 
      cognitive function. However, no study has investigated the relationship between 
      the serum BDNF levels and decision-making. We compared patients with 
      schizophrenia to healthy controls with respect to their decision-making ability 
      and serum BDNF levels. Eighty-six chronic schizophrenia patients and 51 healthy 
      controls participated in this study. We controlled for gender, age, and estimated 
      intelligence quotient (IQ), and we investigated the differences in 
      decision-making performance on the Iowa Gambling Task (IGT) between the 
      schizophrenia patient and control groups. We also compared the IGT scores, the 
      serum BDNF levels, and the clinical symptoms between the groups. The IGT scores 
      of the schizophrenia patients were lower than those of the controls. A negative 
      correlation was detected between the mean net scores on the trials in the final 
      two blocks and the serum BDNF levels (p < 0.05). Multiple regression analysis 
      revealed that depressive symptoms and the serum BDNF levels were significantly 
      associated with the mean net scores on the trials in the final two blocks. Based 
      on these results, impaired sensitivity to both reward and punishment is 
      associated with depressive symptoms and reduced serum BDNF levels in chronic 
      schizophrenia patients and may be related to their poor performance on the IGT.
FAU - Hori, Hikaru
AU  - Hori H
AD  - Department of Psychiatry, University of Occupational and Environmental Health 
      Kitakyushu, Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, University of Occupational and Environmental Health 
      Kitakyushu, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, University of Occupational and Environmental Health 
      Kitakyushu, Japan.
FAU - Atake, Kiyokazu
AU  - Atake K
AD  - Department of Psychiatry, University of Occupational and Environmental Health 
      Kitakyushu, Japan.
FAU - Nakamura, Jun
AU  - Nakamura J
AD  - Department of Psychiatry, University of Occupational and Environmental Health 
      Kitakyushu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20141204
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4255599
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cognition
OT  - decision-making
OT  - depression
OT  - gambling task
OT  - schizophrenia
EDAT- 2014/12/30 06:00
MHDA- 2014/12/30 06:01
PMCR- 2014/01/01
CRDT- 2014/12/25 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/11/14 00:00 [accepted]
PHST- 2014/12/25 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2014/12/30 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2014.00417 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Dec 4;8:417. doi: 10.3389/fnbeh.2014.00417. 
      eCollection 2014.