PMID- 25538910
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141224
LR  - 20200929
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 3
DP  - 2014
TI  - Some side effects and effcts on physical activity of second-generation 
      antipsychotics: A study in children and adolescents.
PG  - 224
LID - 10.4103/2277-9175.145696 [doi]
LID - 224
AB  - BACKGROUND: This study was designed to investigate the metabolic adverse effects 
      (AEs) of second-generation antipsychotics (SGAs) and their relationship with 
      physical activity and non-metabolic AE in children and adolescents. MATERIALS AND 
      METHODS: After exclusion of patients with metabolic syndrome, 62 patients (34 
      children, 28 adolescents) of both genders who were candidates for SGA therapy 
      were selected. Metabolic parameters included fasting blood glucose (FBG), 
      triglyceride (TG), blood pressure (BP), and waist circumference (WC); 
      non-metabolic AEs and physical activity were evaluated at baseline, 1 month, and 
      3 months after starting the treatment. RESULTS: Mean of post-treatment FBG and TG 
      were significantly higher than the baseline values (P < 0.0001). Compared to the 
      baseline value, significantly more patients developed abnormally high (AbH) FBG 
      at the end point (P = 0.02). There was no significant difference in the frequency 
      of patients with AbH-FBG either at the baseline or at the end point (P > 0.05). 
      The frequency of patients with AbH-TG at the end point was not significantly 
      higher than those with baseline AbH-TG (P = 0.10). Although no patient was obese 
      at baseline, 11 (18%) patients developed abdominal obesity at the end point (P < 
      0.0001). There was no significant difference in the frequency of non-metabolic AE 
      (P > 0.05). There was no significant correlation between metabolic and 
      non-metabolic AE (P > 0.05). Frequency of inactive patients was significantly 
      more than the baseline value (P-0.008), and abdominal obesity was significantly 
      more prevalent in less active participants (P = 0.03). CONCLUSION: The present 
      study showed the AE of SGA on FBG and TG, but no effect on BP and WC. We also 
      found that children are more prone to develop abnormally high FBG.
FAU - Arman, Soroor
AU  - Arman S
AD  - Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Sadeghye, Tahere
AU  - Sadeghye T
AD  - Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Bidaki, Reza
AU  - Bidaki R
AD  - Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20141129
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4260272
OTO - NOTNLM
OT  - Adolescents
OT  - children
OT  - metabolic adverse effects
OT  - obesity
OT  - second-generation antipsychotics
COIS- Conflict of Interest: None declared.
EDAT- 2014/12/30 06:00
MHDA- 2014/12/30 06:01
PMCR- 2014/11/29
CRDT- 2014/12/25 06:00
PHST- 2013/03/27 00:00 [received]
PHST- 2013/09/28 00:00 [accepted]
PHST- 2014/12/25 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2014/12/30 06:01 [medline]
PHST- 2014/11/29 00:00 [pmc-release]
AID - ABR-3-224 [pii]
AID - 10.4103/2277-9175.145696 [doi]
PST - epublish
SO  - Adv Biomed Res. 2014 Nov 29;3:224. doi: 10.4103/2277-9175.145696. eCollection 
      2014.