PMID- 25539555
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20220330
IS  - 1300-0144 (Print)
IS  - 1300-0144 (Linking)
VI  - 44
IP  - 5
DP  - 2014
TI  - Polymorphisms in MMP-2 and TIMP-2 in Turkish patients with prostate cancer.
PG  - 839-43
AB  - AIM: Prostate cancer is the most commonly diagnosed malignancy and the second 
      most common cause of cancer deaths in the Western male population. Matrix 
      metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the 
      remodeling of the extracellular matrix (ECM). The imbalance between MMPs and 
      TIMPs may lead to an emergence of pathological processes such as cancer. In this 
      study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) 
      polymorphisms and prostate cancer in the Turkish population was investigated. 
      MATERIALS AND METHODS: Sixty-one prostate cancer patients and 46 healthy subjects 
      were included in the study. DNA was isolated from 2 mL of peripheral blood taken 
      from subjects, and genotypes were analyzed by the polymerase chain 
      reaction-restriction fragment length polymorphism method. RESULTS: The TIMP-2 
      -418 (GC) genotype was found in 15 cases (32.6%) in the control group and in 9 
      cases (14.8%) in the patients group, and statistical significance was determined 
      (P = 0.037, OR = 0.346). The MMP-2 -1306 (CT) genotype was found 2.17 times more 
      in the patient group than in the control group (P = 0.149, OR = 2.17). 
      CONCLUSION: Our results show that the TIMP-2 -418 (GC) genotype had a putative 
      protective effect against prostate cancer.
FAU - Yaykasli, Kursat Oguz
AU  - Yaykasli KO
FAU - Kayikci, Muhammet Ali
AU  - Kayikci MA
FAU - Yamak, Nesibe
AU  - Yamak N
FAU - Soguktas, Hatice
AU  - Soguktas H
FAU - Duzenli, Selma
AU  - Duzenli S
FAU - Arslan, Ali Osman
AU  - Arslan AO
FAU - Metin, Ahmet
AU  - Metin A
FAU - Kaya, Ertugrul
AU  - Kaya E
FAU - Hatipoglu, Omer Faruk
AU  - Hatipoglu OF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 2/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prostatic Neoplasms/*genetics
MH  - Tissue Inhibitor of Metalloproteinase-2/*genetics
EDAT- 2014/12/30 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/12/26 06:00
PHST- 2014/12/26 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PST - ppublish
SO  - Turk J Med Sci. 2014;44(5):839-43.