PMID- 25539739
OWN - NLM
STAT- MEDLINE
DCOM- 20151006
LR  - 20221207
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 14
DP  - 2014 Dec 24
TI  - Association between brain-derived neurotrophic factor genetic polymorphism 
      Val66Met and susceptibility to bipolar disorder: a meta-analysis.
PG  - 366
LID - 10.1186/s12888-014-0366-9 [doi]
LID - 366
AB  - BACKGROUND: In view of previous conflicting findings, this meta-analysis was 
      performed to comprehensively determine the overall strength of associations 
      between brain-derived neurotrophic factor (BDNF) genetic polymorphism Val66Met 
      and susceptibility to bipolar disorders (BPD). METHODS: Literatures published and 
      cited in Pubmed and Wanfang Data was searched with terms of 'Val66Met', 'G196A', 
      'rs6265', 'BDNF', 'association', and 'bipolar disorder' up to March 2014. All 
      original case-control association studies were meta-analyzed with a pooled OR to 
      estimate the risk and 95% confidence interval (CI) to reflect the magnitude of 
      variance. RESULTS: Twenty-one case-control association studies met our criteria 
      for the meta-analysis. Overall, there was no significant difference in allelic 
      distribution of Val66Met polymorphism between patients and controls with a pooled 
      OR = 1.03 (95% CI 0.98, 1.08) although there was a trend towards association 
      between Val66Met polymorphism and BPD in Caucasians with an OR of 1.08 (95% CI 
      1.00, 1.16). However, subgroup analyses showed that there was a significant 
      association of Val allele with decreased disease susceptibility for bipolar 
      disorder type II with a pooled OR of 0.88 (95% CI 0.78, 0.99). CONCLUSIONS: There 
      is no compelling evidence to supportVal66Met polymorphism in BDNF gene playing an 
      important role in the susceptibility to BPD across different ethnicities.
FAU - Wang, Zuowei
AU  - Wang Z
AD  - Division of Mood Disorders, Hongkou District Mental Health Center of Shanghai, 
      Shanghai, 200083, P. R. China. wzwhk@163.com.
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200030, P. R. China. wzwhk@163.com.
FAU - Li, Zezhi
AU  - Li Z
AD  - Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, 200127, P. R. China. lizezhi1981@aliyun.com.
FAU - Gao, Keming
AU  - Gao K
AD  - Department of Psychiatry, Mood and Anxiety Clinic in the Mood Disorders Program, 
      University Hospitals Case Medical Center/Case Western Reserve University School 
      of Medicine, Cleveland, Ohio, 44106, USA. Keming.Gao@UHhospitals.org.
FAU - Fang, Yiru
AU  - Fang Y
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200030, P. R. China. 
      yirufang@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141224
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Asian People/genetics
MH  - Bipolar Disorder/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Methionine/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Valine/genetics
MH  - White People/genetics
PMC - PMC4297385
EDAT- 2014/12/30 06:00
MHDA- 2015/10/07 06:00
PMCR- 2014/12/24
CRDT- 2014/12/26 06:00
PHST- 2014/08/31 00:00 [received]
PHST- 2014/12/17 00:00 [accepted]
PHST- 2014/12/26 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/10/07 06:00 [medline]
PHST- 2014/12/24 00:00 [pmc-release]
AID - s12888-014-0366-9 [pii]
AID - 366 [pii]
AID - 10.1186/s12888-014-0366-9 [doi]
PST - epublish
SO  - BMC Psychiatry. 2014 Dec 24;14:366. doi: 10.1186/s12888-014-0366-9.