PMID- 25541389
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20220409
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 8
IP  - 2
DP  - 2015 Mar-Apr
TI  - The ACDC pilot trial: targeting the anterior cingulate by double cone coil rTMS 
      for the treatment of depression.
PG  - 240-6
LID - S1935-861X(14)00389-1 [pii]
LID - 10.1016/j.brs.2014.11.014 [doi]
AB  - BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) of the 
      dorsolateral-prefrontal cortex (DLPFC) with conventional figure-of-8 (=butterfly) 
      coils has been used as an antidepressant therapeutic tool for almost twenty 
      years. Very recently, an innovative rTMS coil, the so-called double cone coil 
      (DC), was introduced allowing the modulation of the anterior cingulate cortex 
      (AC). We investigated safety and therapeutic effectiveness of this stimulation in 
      a naturalistic clinical setting. METHOD: Forty-five patients suffering a moderate 
      to severe depressive episode were randomized to receive 15 sessions of either 
      conventional rTMS of the left DLPFC ("butterfly-rTMS"; 10 Hz; 2000 stimuli/day, 
      RMT 110%), mediofrontal double cone coil stimulation of the anterior cingulate 
      cortex ("ACDC-rTMS" with equal parameters), or sham-stimulation. The primary 
      outcome was the change in the 21-items Hamilton Rating Scale for Depression 
      (HAMD) from baseline to the end of treatment. Secondary outcome measures were 
      changes over the course of the trial regarding the HAMD, the Beck Depression 
      Inventory (BDI), the Clinical Global Impression (CGI) and the Global Assessment 
      of Functioning (GAF) scales. RESULTS: There was a significant group x time 
      interaction effect regarding the primary outcome (F = 3.269; df = 2,37; 
      P = 0.049). Post-hoc t-testing revealed a significant effect for the comparison 
      ACDC vs. butterfly at week 3/end of treatment (T = 2.646; df = 26; P = 0.014). No 
      severe adverse events occurred during the study. ACDC-stimulation was well 
      tolerated by the majority of patients similar like butterfly-rTMS and 
      sham-stimulation. CONCLUSION: This pilot study demonstrated the feasibility of 
      ACDC-rTMS-stimulation as an add-on-treatment for depression. Its clinical effects 
      warrant further investigation in the future.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kreuzer, Peter M
AU  - Kreuzer PM
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany. 
      Electronic address: peter.kreuzer@medbo.de.
FAU - Schecklmann, Martin
AU  - Schecklmann M
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
FAU - Lehner, Astrid
AU  - Lehner A
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
FAU - Wetter, Thomas C
AU  - Wetter TC
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
FAU - Poeppl, Timm B
AU  - Poeppl TB
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
FAU - Rupprecht, Rainer
AU  - Rupprecht R
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
FAU - de Ridder, Dirk
AU  - de Ridder D
AD  - Unit of Neurosurgery, Department of Surgical Sciences, Dunedin School of 
      Medicine, University of Otago, Dunedin, New Zealand; Brain Research Center 
      Antwerp for Innovative & Interdisciplinary Neuromodulation, Sint-Augustinus 
      Hospital, Belgium.
FAU - Landgrebe, Michael
AU  - Landgrebe M
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany; 
      Department of Psychiatry, Psychosomatics and Psychotherapy, 
      Kbo-Lech-Mangfall-Klinik Agatharied, Germany.
FAU - Langguth, Berthold
AU  - Langguth B
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20141129
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
SB  - IM
MH  - Adult
MH  - Depression/*therapy
MH  - Female
MH  - Gyrus Cinguli/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prefrontal Cortex/physiology
MH  - Psychiatric Status Rating Scales
MH  - Transcranial Magnetic Stimulation/adverse effects/*instrumentation
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Double cone coil
OT  - Major depression
OT  - Repetitive transcranial magnetic stimulation
EDAT- 2014/12/30 06:00
MHDA- 2015/05/23 06:00
CRDT- 2014/12/27 06:00
PHST- 2014/07/27 00:00 [received]
PHST- 2014/11/24 00:00 [revised]
PHST- 2014/11/24 00:00 [accepted]
PHST- 2014/12/27 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - S1935-861X(14)00389-1 [pii]
AID - 10.1016/j.brs.2014.11.014 [doi]
PST - ppublish
SO  - Brain Stimul. 2015 Mar-Apr;8(2):240-6. doi: 10.1016/j.brs.2014.11.014. Epub 2014 
      Nov 29.