PMID- 25541655
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20181113
IS  - 1300-7777 (Print)
IS  - 1308-5263 (Electronic)
IS  - 1300-7777 (Linking)
VI  - 31
IP  - 4
DP  - 2014 Dec 5
TI  - The relationship of T helper-2 pathway components interleukin-4, interleukin-10, 
      immunoglobulin e, and eosinophils with prognostic markers in non-hodgkin 
      lymphoma: a case-control study.
PG  - 381-7
LID - 10.4274/tjh.2013.0328 [doi]
AB  - OBJECTIVE: Increased risk for non-Hodgkin lymphoma (NHL) is associated with 
      infections and environmental agents. We hypothesized that these factors 
      chronically trigger the T helper-2 (Th2) pathway and result in lymphoma. We 
      investigated the role of the Th2 pathway by exploring the relationships between 
      components of the Th2 pathway, interleukin (IL)-10, IL-4, immunoglobulin E (IgE), 
      and eosinophils, and prognostic markers of NHL. MATERIALS AND METHODS: Thirty-one 
      NHL patients and 27 healthy controls were enrolled. IL-10, IL-4, IgE, and 
      eosinophils were measured. IL-4 and IL-10 were analyzed with the enzyme amplified 
      sensitivity immunoassay method. RESULTS: High IL-10 levels were correlated with 
      several poor prognostic features, short early survival, and lymphopenia. There 
      was a positive correlation between albumin and IL-4 levels and a negative 
      correlation between IL-10 and albumin. There was no relationship related with 
      eosinophils and IgE. We found remnant increased IL-4, which could be a clue for 
      the triggering of the Th2 pathway in the background. CONCLUSION: There is a need 
      for differently designed studies to detect the place of the Th2 pathway in NHL.
FAU - Guler, Nil
AU  - Guler N
AD  - 19 Mayis University Faculty of Medicine, Department of Hematology, Samsun, 
      Turkey. E-ma-il: nilvecay@yahoo.com.
FAU - Kelkitli, Engin
AU  - Kelkitli E
FAU - Atay, Hilmi
AU  - Atay H
FAU - Erdem, Dilek
AU  - Erdem D
FAU - Alacam, Hasan
AU  - Alacam H
FAU - Bek, Yuksel
AU  - Bek Y
FAU - Ozatli, Duzgun
AU  - Ozatli D
FAU - Turgut, Mehmet
AU  - Turgut M
FAU - Yildiz, Levent
AU  - Yildiz L
FAU - Yucel, Idris
AU  - Yucel I
LA  - eng
PT  - Journal Article
TT  - Yardimci T Lenfosit-2 Yolagi Bilesenlerinden Interlokin-4, Interlokin-10, 
      Immunglobulin E ve Eozinofiller'in Hodgkin-Disi Lenfoma'nin Prognostik 
      Belirtecleri ile Olan Iliskisi-Kontrollu Klinik Calisma.
PL  - Turkey
TA  - Turk J Haematol
JT  - Turkish journal of haematology : official journal of Turkish Society of 
      Haematology
JID - 9606065
PMC - PMC4454053
EDAT- 2014/12/30 06:00
MHDA- 2014/12/30 06:01
PMCR- 2014/12/01
CRDT- 2014/12/27 06:00
PHST- 2014/12/27 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2014/12/30 06:01 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - 1331 [pii]
AID - 10.4274/tjh.2013.0328 [doi]
PST - ppublish
SO  - Turk J Haematol. 2014 Dec 5;31(4):381-7. doi: 10.4274/tjh.2013.0328.