PMID- 25542148
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20150120
IS  - 1432-0703 (Electronic)
IS  - 0090-4341 (Linking)
VI  - 68
IP  - 2
DP  - 2015 Feb
TI  - Salinity-dependent nickel accumulation and oxidative stress responses in the 
      euryhaline killifish (Fundulus heteroclitus).
PG  - 382-94
LID - 10.1007/s00244-014-0115-6 [doi]
AB  - The mechanisms of nickel (Ni) toxicity in marine fish remain unclear, although 
      evidence from freshwater (FW) fish suggests that Ni can act as a pro-oxidant. 
      This study investigated the oxidative stress effects of Ni on the euryhaline 
      killifish (Fundulus heteroclitus) as a function of salinity. Killifish were 
      exposed to sublethal levels (5, 10, and 20 mg L(-1)) of waterborne Ni for 96 h in 
      FW (0 ppt) and 100 % saltwater (SW) (35 ppt). In general, SW was protective 
      against both Ni accumulation and indicators of oxidative stress [protein carbonyl 
      formation and catalase (CAT) activity]. This effect was most pronounced at the 
      highest Ni exposure level. For example, FW intestine showed increased Ni 
      accumulation relative to SW intestine at 20 mg Ni L(-1), and this was accompanied 
      by significantly greater protein carbonylation and CAT activity in this tissue. 
      There were exceptions, however, in that although liver of FW killifish at the 
      highest exposure concentration showed greater Ni accumulation relative to SW 
      liver, levels of CAT activity were greatly decreased. This may relate to tissue- 
      and salinity-specific differences in oxidative stress responses. The results of 
      the present study suggest (1) that there was Ni-induced oxidative stress in 
      killifish, (2) that the effects of salinity depend on differences in the 
      physiology of the fish in FW versus SW, and (3) that increased levels of cations 
      (sodium, calcium, potassium, and magnesium) and anions (SO4 and Cl) in SW are 
      likely protective against Ni accumulation in tissues exposed to the aquatic 
      environment.
FAU - Blewett, Tamzin A
AU  - Blewett TA
AD  - Department of Biology, McMaster University, Life Science Building, 1280 Main 
      St.W., Hamilton, ON, L8S 4K1, Canada, blewetta@mcmaster.ca.
FAU - Wood, Chris M
AU  - Wood CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141227
PL  - United States
TA  - Arch Environ Contam Toxicol
JT  - Archives of environmental contamination and toxicology
JID - 0357245
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Water Pollutants, Chemical)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - Animals
MH  - Fundulidae/metabolism
MH  - Nickel/*metabolism/toxicity
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/metabolism
MH  - *Salinity
MH  - Water Pollutants, Chemical/*metabolism/toxicity
EDAT- 2014/12/30 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/12/28 06:00
PHST- 2014/07/27 00:00 [received]
PHST- 2014/11/28 00:00 [accepted]
PHST- 2014/12/28 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - 10.1007/s00244-014-0115-6 [doi]
PST - ppublish
SO  - Arch Environ Contam Toxicol. 2015 Feb;68(2):382-94. doi: 
      10.1007/s00244-014-0115-6. Epub 2014 Dec 27.