PMID- 25543093
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20150902
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 21
IP  - 4
DP  - 2015 Apr
TI  - Acute cholecystitis is a common complication after allogeneic stem cell 
      transplantation and is associated with the use of total parenteral nutrition.
PG  - 768-71
LID - S1083-8791(14)01398-6 [pii]
LID - 10.1016/j.bbmt.2014.12.005 [doi]
AB  - The incidence and risk factors for acute cholecystitis after allogeneic 
      hematopoietic stem cell transplantation (HSCT) are not well defined. Of 644 
      consecutive adult transplants performed at our institution between 2001 and 2011, 
      acute cholecystitis occurred in the first year of transplant in 32 patients 
      (5.0%). We conducted 2 retrospective case-control studies of this population to 
      determine risk factors for cholecystitis after HSCT and to evaluate the 
      performance of different methods of imaging to diagnosis cholecystitis in 
      patients undergoing HSCT compared with non-HSCT patients. In the HSCT population, 
      development of cholecystitis was associated with an increased 1-year overall 
      mortality rate (62.5% versus 19.8%, P < .001). The risk of developing 
      cholecystitis was higher in patients who received total parenteral nutrition 
      (TPN) (adjusted odds ratio, 3.41; P = .009). There was a trend toward more 
      equivocal abdominal ultrasound findings in HSCT recipients with acute 
      cholecystitis compared with nontransplant patients (50.0% versus 30.6%, P = .06). 
      However, hepatobiliary iminodiacetic acid (HIDA) scans were definitively positive 
      for acute cholecystitis in most patients in both populations (80.0% of HSCT 
      recipients versus 77.4% of control subjects, P = .82). In conclusion, acute 
      cholecystitis is a common early complication of HSCT, the risk is increased in 
      patients who receive TPN, and it is associated with high 1-year mortality. In 
      HSCT recipients with findings suggestive of acute cholecystitis, especially those 
      receiving TPN, early use of HIDA scan may be considered over ultrasound.
CI  - Copyright (c) 2015 American Society for Blood and Marrow Transplantation. Published 
      by Elsevier Inc. All rights reserved.
FAU - Bagley, Stephen J
AU  - Bagley SJ
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania. Electronic address: Stephen.bagley@uphs.upenn.edu.
FAU - Sehgal, Alison R
AU  - Sehgal AR
AD  - Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, 
      Pittsburgh, Pennsylvania.
FAU - Gill, Saar
AU  - Gill S
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Frey, Noelle V
AU  - Frey NV
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Hexner, Elizabeth O
AU  - Hexner EO
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Loren, Alison W
AU  - Loren AW
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Mangan, James K
AU  - Mangan JK
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Porter, David L
AU  - Porter DL
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Stadtmauer, Edward A
AU  - Stadtmauer EA
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Reshef, Ran
AU  - Reshef R
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Luger, Selina M
AU  - Luger SM
AD  - Abramson Cancer Center of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
LA  - eng
PT  - Journal Article
DEP - 20141224
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Allografts
MH  - Cholecystitis/*diagnosis/*epidemiology/*etiology
MH  - Female
MH  - Hematologic Neoplasms/epidemiology/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parenteral Nutrition/*adverse effects
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Acute cholecystitis
OT  - Allogeneic
OT  - Hematopoietic stem cell transplantation
OT  - Risk factor
OT  - Total parenteral nutrition
OT  - Ultrasound
EDAT- 2014/12/30 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/12/28 06:00
PHST- 2014/09/27 00:00 [received]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2014/12/28 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1083-8791(14)01398-6 [pii]
AID - 10.1016/j.bbmt.2014.12.005 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2015 Apr;21(4):768-71. doi: 
      10.1016/j.bbmt.2014.12.005. Epub 2014 Dec 24.