PMID- 25543333
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20200109
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Feb
TI  - Diverse glial cell line-derived neurotrophic factor (GDNF) support between mania 
      and schizophrenia: a comparative study in four major psychiatric disorders.
PG  - 198-204
LID - S0924-9338(14)00644-0 [pii]
LID - 10.1016/j.eurpsy.2014.11.003 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) and glial cell line-derived 
      neurotrophic factor (GDNF) have essential roles in synaptic plasticity which is 
      involved in pathogenesis and treatment of psychiatric disorders. However, it is 
      not clear whether they act simultaneously during illness states in major 
      psychiatric disorders. METHODS: BDNF and GDNF serum levels were measured 
      concomitantly by enzyme-linked immunosorbent assay (ELISA) method in 171 patients 
      diagnosed with schizophrenia (n=33), bipolar disorder-manic episode (n=39), 
      bipolar/unipolar depression (n=64, 24/40) and obsessive-compulsive disorder 
      (n=35) according to DSM-IV, and 78 healthy volunteers. SCID-I and SCID 
      non-patient version were used for clinical evaluation of the patients and healthy 
      volunteers, respectively. Correlations between the two trophic factor levels, and 
      illness severity scores, duration of illness and medication dosages were studied 
      across different illnesses. RESULTS: While patients had equally lower BDNF levels 
      in all diagnoses, GDNF levels were significantly higher in mania and lower in 
      schizophrenia compared to healthy controls. BDNF levels were negatively 
      correlated to illness severity scores in affective episodes (mania and 
      depression). Longer duration of illness (>5 years) had an impact on lower GDNF 
      levels in schizophrenia. BDNF levels and antipsychotic drug dosages in 
      schizophrenia, and GDNF levels and antidepressant drug dosages in 
      obsessive-compulsive disorder were positively correlated. CONCLUSION: Our data 
      confirmed the evidence of equally deficient neuronal support by BDNF in all major 
      psychiatric illnesses, but suggested a diverse glial functioning between 
      schizophrenia and mania.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Tunca, Z
AU  - Tunca Z
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey. Electronic address: 
      zeliha.tunca@deu.edu.tr.
FAU - Kivircik Akdede, B
AU  - Kivircik Akdede B
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Ozerdem, A
AU  - Ozerdem A
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Alkin, T
AU  - Alkin T
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Polat, S
AU  - Polat S
AD  - Manisa, Turkey.
FAU - Ceylan, D
AU  - Ceylan D
AD  - Gumushane, Turkey.
FAU - Bayin, M
AU  - Bayin M
AD  - Nigde, Turkey.
FAU - Cengizcetin Kocuk, N
AU  - Cengizcetin Kocuk N
AD  - Bingol, Turkey.
FAU - Simsek, S
AU  - Simsek S
AD  - Hatay, Turkey.
FAU - Resmi, H
AU  - Resmi H
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Akan, P
AU  - Akan P
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141224
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Antipsychotic Agents)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Bipolar Disorder/*blood/physiopathology
MH  - Depressive Disorder, Major/*blood/physiopathology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obsessive-Compulsive Disorder/*blood/physiopathology
MH  - Schizophrenia/*blood/physiopathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Depression
OT  - Glial cell line-derived neurotrophic factor (GDNF)
OT  - Mania
OT  - Obsessive-compulsive disorder
OT  - Schizophrenia
EDAT- 2014/12/30 06:00
MHDA- 2016/04/08 06:00
CRDT- 2014/12/29 06:00
PHST- 2014/09/30 00:00 [received]
PHST- 2014/11/14 00:00 [revised]
PHST- 2014/11/14 00:00 [accepted]
PHST- 2014/12/29 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
AID - S0924-9338(14)00644-0 [pii]
AID - 10.1016/j.eurpsy.2014.11.003 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2015 Feb;30(2):198-204. doi: 10.1016/j.eurpsy.2014.11.003. Epub 
      2014 Dec 24.