PMID- 25543384
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 118
IP  - 11
DP  - 2014 Nov
TI  - [Polypoidal choroidal vasculopathy: new observations and therapeutic 
      implications].
PG  - 927-42
AB  - Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related 
      macular degeneration characterized by peculiar polypoidal lesions seen on 
      indocyanine green angiography (IA). However, precise pathogenesis of PCV has yet 
      to be clearly elucidated. In addition to the conventional diagnostic tools, we 
      evaluated the clinical characteristics of PCV by means of relatively new and 
      noninvasive imaging methods, namely, fundus autofluorescence photography and 
      enhanced depth imaging optical coherence tomography, and found novel 
      observations. This article focuses especially on the relationship between the 
      clinical characteristics of PCV and choroidal vascular hyperpermeability. 
      Choroidal vascular hyperpermeability, which is visualized as multifocal 
      hyperfluorescence in the middle and late phases on IA, was originally described 
      as a characteristic finding in, central serous chorioretinopathy (CSC). Of the 89 
      patients with PCV in our case series, 31 patients (34.8%) demonstrated choroidal 
      vascular hyperpermeability. The patients with PCV associated with choroidal 
      vascular hyperpermeability demonstrated more frequently bilateral occurrence of 
      neovascular membrane, a history of CSC, a thickened choroid and poor responses to 
      ranibizumab therapy than those without choroidal vascular hyperpermeability. Our 
      results provide further understanding of PCV and new therapeutic implications.
FAU - Koizumi, Hideki
AU  - Koizumi H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
SB  - IM
MH  - Age Distribution
MH  - Choroidal Neovascularization/pathology/*therapy
MH  - Humans
MH  - Risk Factors
MH  - Sex Characteristics
EDAT- 2014/12/30 06:00
MHDA- 2015/03/04 06:00
CRDT- 2014/12/30 06:00
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 2014 Nov;118(11):927-42.