PMID- 25544696
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 98
DP  - 2015 Feb
TI  - Dietary conjugated linoleic acid and its effect on immune response in pigs 
      infected with the porcine reproductive and respiratory syndrome virus.
PG  - 30-8
LID - S0034-5288(14)00348-8 [pii]
LID - 10.1016/j.rvsc.2014.12.007 [doi]
AB  - The aim of this study was to evaluate the effects of dietary conjugated linoleic 
      acid (CLA) on immune response in pigs infected with porcine reproductive and 
      respiratory syndrome virus (PRRSV). A total of 18 pigs 4 weeks of age were 
      allocated to 3 treatments, 6 per treatment: 0% CLA, 1% CLA, and 2% CLA. Serum 
      IL-1beta, IL-6 and TNF-alpha; lymphocyte proliferation; and IL-2, IFN-gamma, IL-10, IL-4 and 
      IL-12 in PBMCs were evaluated. NF-kappaB, COX2, iNOS and PPAR-gamma mRNA were also 
      evaluated. No differences were observed among treatment groups in most of the in 
      vivo cytokine profiles; only TNF-alpha production was increased in infected pigs in 
      the CLA-supplemented groups. The cytokine profile in vitro was not affected by 
      CLA supplementation. CLA decreased the proliferation of PBMCs stimulated with 
      PRRSVs. Inflammation mediators and PPAR-gamma were not affected by CLA in infected 
      pigs. CLA did not improve the immune response of PRRSV infected pigs.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Pinelli-Saavedra, A
AU  - Pinelli-Saavedra A
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico. Electronic address: pinelli@ciad.mx.
FAU - Peralta-Quintana, J R
AU  - Peralta-Quintana JR
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico.
FAU - Sosa-Castaneda, J
AU  - Sosa-Castaneda J
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico.
FAU - Moya-Camarena, S Y
AU  - Moya-Camarena SY
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico.
FAU - Burgara-Estrella, A
AU  - Burgara-Estrella A
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico.
FAU - Hernandez, J
AU  - Hernandez J
AD  - Department of Nutrition and Metabolism, Centro de Investigacion en Alimentacion y 
      Desarrollo, A.C. (CIAD) Apdo. Postal 1735, Carretera a la Victoria Km 0.6, 
      Hermosillo, Sonora 83304, Mexico.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141215
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
RN  - 0 (Linoleic Acids, Conjugated)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cell Proliferation/drug effects
MH  - Cytokines/metabolism
MH  - *Dietary Supplements
MH  - Immunity, Innate/*drug effects/*immunology
MH  - Linoleic Acids, Conjugated/*pharmacology
MH  - NF-kappa B/blood
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Sus scrofa/*immunology
MH  - Swine
MH  - Th1 Cells/metabolism/pathology
MH  - Th2 Cells/metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - CLA supplementation
OT  - Immune response
OT  - PRRSV
EDAT- 2014/12/30 06:00
MHDA- 2015/09/16 06:00
CRDT- 2014/12/30 06:00
PHST- 2014/09/02 00:00 [received]
PHST- 2014/12/03 00:00 [revised]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - S0034-5288(14)00348-8 [pii]
AID - 10.1016/j.rvsc.2014.12.007 [doi]
PST - ppublish
SO  - Res Vet Sci. 2015 Feb;98:30-8. doi: 10.1016/j.rvsc.2014.12.007. Epub 2014 Dec 15.