PMID- 25545116
OWN - NLM
STAT- MEDLINE
DCOM- 20150318
LR  - 20181202
IS  - 1365-3024 (Electronic)
IS  - 0141-9838 (Linking)
VI  - 37
IP  - 2
DP  - 2015 Feb
TI  - Tick saliva increases production of three chemokines including monocyte 
      chemoattractant protein-1, a histamine-releasing cytokine.
PG  - 92-6
LID - 10.1111/pim.12168 [doi]
AB  - The effect of Ixodes ricinus tick saliva on the production of various cytokines 
      and chemokines by mouse splenocytes was tested by a cytokine array. We 
      demonstrated a strong upregulation of three chemokines, monocyte chemoattractant 
      protein-1 (MCP-1), thymus-derived chemotactic agent 3 (TCA-3) and macrophage 
      inflammatory protein 2 (MIP-2). MCP-1 could be induced by tick saliva itself. 
      While TCA-3 and MIP-2 are engaged in Th2 polarization of the host immune response 
      associated with tick feeding, MCP-1 may act as a histamine release factor, 
      increasing blood flow into the feeding lesion thus facilitating tick engorgement 
      in the late, rapid feeding phase.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Langhansova, H
AU  - Langhansova H
AD  - Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech 
      Republic; Biology centre of the AS CR, Institute of Parasitology, Ceske 
      Budejovice, Czech Republic.
FAU - Bopp, T
AU  - Bopp T
FAU - Schmitt, E
AU  - Schmitt E
FAU - Kopecky, J
AU  - Kopecky J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 0 (Chemokine CCL1)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL2)
SB  - IM
MH  - Animals
MH  - Chemokine CCL1/*immunology
MH  - Chemokine CCL2/*immunology
MH  - Chemokine CXCL2/*immunology
MH  - Female
MH  - Histamine Release
MH  - Ixodes/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Saliva/immunology
MH  - Specific Pathogen-Free Organisms
MH  - Th2 Cells/immunology
OTO - NOTNLM
OT  - Ixodes ricinus
OT  - MCP-1
OT  - Th2 response
OT  - chemokine
OT  - histamine
OT  - tick saliva
EDAT- 2014/12/30 06:00
MHDA- 2015/03/19 06:00
CRDT- 2014/12/30 06:00
PHST- 2014/09/10 00:00 [received]
PHST- 2014/12/15 00:00 [accepted]
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/03/19 06:00 [medline]
AID - 10.1111/pim.12168 [doi]
PST - ppublish
SO  - Parasite Immunol. 2015 Feb;37(2):92-6. doi: 10.1111/pim.12168.