PMID- 25545233
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20220408
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 76
DP  - 2015 Mar
TI  - Association of persistent organic pollutants and non-persistent pesticides with 
      diabetes and diabetes-related health outcomes in Asia: A systematic review.
PG  - 57-70
LID - S0160-4120(14)00356-0 [pii]
LID - 10.1016/j.envint.2014.12.001 [doi]
AB  - BACKGROUND: Over half of the people with diabetes in the world live in Asia. 
      Emerging scientific evidence suggests that diabetes is associated with 
      environmental pollutants, exposures that are also abundant in Asia. OBJECTIVE: To 
      systematically review the literature concerning the association of persistent 
      organic pollutants (POPs) and non-persistent pesticides with diabetes and 
      diabetes-related health outcomes in Asia. METHODS: PubMed and Embase were 
      searched to identify studies published up to November 2014. A secondary reference 
      review of all extracted articles and the National Toxicology Program Workshop on 
      the association of POPs with diabetes was also conducted. A total of 19 articles 
      met the inclusion criteria and were evaluated in this review. RESULTS: To date, 
      the evidence relating POPs and non-persistent pesticides with diabetes in Asian 
      populations is equivocal. Positive associations were reported between serum 
      concentrations of polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs), 
      polychlorinated biphenyls (PCBs), and several organochlorine pesticides (DDT, 
      DDE, oxychlordane, trans-nonachlor, hexachlorobenzene, hexachlorocyclohexane) 
      with diabetes. PCDD/Fs were also associated with blood glucose and insulin 
      resistance, but not beta-cell function. There were substantial limitations of the 
      literature including: most studies were cross-sectional, few studies addressed 
      selection bias and confounding, and most effect estimates had exceptionally wide 
      confidence intervals. Few studies evaluated the effects of organophosphates. 
      CONCLUSIONS: Well-conducted research is urgently needed on these pervasive 
      exposures to inform policies to mitigate the diabetes epidemic in Asia.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Jaacks, Lindsay M
AU  - Jaacks LM
AD  - Department of Nutrition, Gillings School of Global Public Health, The University 
      of North Carolina, Chapel Hill, NC, USA.
FAU - Staimez, Lisa R
AU  - Staimez LR
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA, USA. Electronic address: lisa.staimez@emory.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20141226
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Blood Glucose)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Halogenated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Asia/epidemiology
MH  - Blood Glucose/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/blood/*epidemiology
MH  - Environmental Exposure/*analysis
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hydrocarbons, Halogenated/*blood
MH  - Insulin Resistance/physiology
MH  - Pesticides/*blood
OTO - NOTNLM
OT  - Asia
OT  - Beta-cell function
OT  - Diabetes
OT  - Insulin resistance
OT  - Non-persistent pesticides
OT  - Persistent organic pollutants
EDAT- 2014/12/30 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/12/30 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2014/12/03 00:00 [revised]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0160-4120(14)00356-0 [pii]
AID - 10.1016/j.envint.2014.12.001 [doi]
PST - ppublish
SO  - Environ Int. 2015 Mar;76:57-70. doi: 10.1016/j.envint.2014.12.001. Epub 2014 Dec 
      26.