PMID- 25545603 OWN - NLM STAT- MEDLINE DCOM- 20150825 LR - 20220408 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 174 DP - 2015 Mar 15 TI - Comorbid obsessive compulsive disorder in patients with bipolar-I disorder. PG - 367-71 LID - S0165-0327(14)00805-2 [pii] LID - 10.1016/j.jad.2014.12.019 [doi] AB - BACKGROUND: Limited numbers of studies have examined the prevalence of OCD systematically in consecutively sampled adult bipolar disorder type I (BD-I) patients. We examined the frequency of OCD in a large number (n=396) of consecutively hospitalized patients with BD-I and identified socio-demographic and clinical correlates of BD-I with and without OCD. METHOD: BD-I patients (n=396) were assessed using the Mini International Neuropsychiatric Interview for Bipolar Disorder Studies, the Structured clinical interview for (Axis II) DSM-IV, the Family interview for genetic studies, the Yale-Brown Obsessive-Compulsive Scale, the Young Mania Rating Scale, the Hamilton Rating Scale for Depression, the Global Assessment of Functioning (GAF) and the Clinical Global Impression scale. Patients with and without OCD were compared in terms of various socio-demographic and clinical variables. RESULTS: Thirty (7.6%) of the 396 inpatients studied had OCD and 15 (3.8%) had subclinical OCD. BD-OCD group had significantly lower GAF scores, higher rates of unemployment, and lower incidence of psychotic symptoms. In addition, BD-OCD group had higher rates of comorbid social anxiety and anxious avoidant personality disorder (AAPD) and OCD in first-degree relatives. Those with clinical and subclinical OCD did not differ on functioning and severity measures. LIMITATIONS: Retrospective design and recruitment of patients from inpatient services of a tertiary psychiatric hospital. CONCLUSION: OCD is not an uncommon comorbid disorder in BD-I and appears to be associated with greater functional disability. BD-I with comorbid OCD is associated with greater family history of OCD, comorbidities of social phobia and AAPD and less of psychotic symptoms. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Shashidhara, M AU - Shashidhara M AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. FAU - Sushma, B R AU - Sushma BR AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. FAU - Viswanath, Biju AU - Viswanath B AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. FAU - Math, Suresh Bada AU - Math SB AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. FAU - Janardhan Reddy, Y C AU - Janardhan Reddy YC AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. Electronic address: ycjreddy@gmail.com. LA - eng PT - Journal Article DEP - 20141213 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Adult MH - Bipolar Disorder/*epidemiology/psychology MH - Case-Control Studies MH - Comorbidity MH - Demography MH - Diagnostic and Statistical Manual of Mental Disorders MH - Female MH - Humans MH - India/epidemiology MH - Male MH - Mental Disorders/*epidemiology MH - Obsessive-Compulsive Disorder/*epidemiology/psychology MH - Prevalence MH - Retrospective Studies MH - Young Adult OTO - NOTNLM OT - Anxiety disorder OT - Bipolar disorder OT - Co-morbidity OT - Obsessive compulsive disorder EDAT- 2014/12/30 06:00 MHDA- 2015/08/26 06:00 CRDT- 2014/12/30 06:00 PHST- 2014/10/23 00:00 [received] PHST- 2014/12/04 00:00 [revised] PHST- 2014/12/04 00:00 [accepted] PHST- 2014/12/30 06:00 [entrez] PHST- 2014/12/30 06:00 [pubmed] PHST- 2015/08/26 06:00 [medline] AID - S0165-0327(14)00805-2 [pii] AID - 10.1016/j.jad.2014.12.019 [doi] PST - ppublish SO - J Affect Disord. 2015 Mar 15;174:367-71. doi: 10.1016/j.jad.2014.12.019. Epub 2014 Dec 13.