PMID- 25546242
OWN - NLM
STAT- MEDLINE
DCOM- 20151223
LR  - 20220330
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 18
IP  - 1
DP  - 2015 Jan
TI  - Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a 
      meta-analysis.
PG  - 17-28
LID - 10.1111/1756-185X.12528 [doi]
AB  - AIM: Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported 
      to be associated with systemic lupus erythematosus (SLE) susceptibility, but the 
      results of these previous studies have been inconsistent. The purpose of the 
      present study was to systematically summarize and explore whether specific 
      HLA-DRB1 alleles confer susceptibility or resistance to SLE and lupus nephritis. 
      METHODS: This review was guided by the preferred reporting items for systematic 
      reviews and meta-analyses (PRISMA) approach. A comprehensive search was made for 
      articles from PubMed, Medline, Elsevier Science, Springer Link and Cochrane 
      Library database. A total of 25 case-control studies on the relationship between 
      gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and 
      processed using Review Manager 5.2 and Stata 11.0. RESULTS: At the allelic level, 
      HLA-DR4, DR11 and DR14 were identified as protective factors for SLE (0.79 
      [0.69,0.91], P < 0.001; 0.72 [0.60, 0.85], P < 0.0001; 0.47 [0.59, 0.95], 
      P < 0.05, respectively). HLA-DR3, DR9, DR15 were potent risk factors for SLE 
      (1.88 [1.58, 2.23], P < 0.001; 1.24 [1.07, 1.45], P < 0.05; 1.25 [1.10, 1.43], 
      P < 0.001, respectively). However, HLA-DR8 was not statistically significant 
      between the SLE group and control group (OR, 1.11 [0.96, 1.30], P > 0.05). DR4 
      and 11 (OR, 0.55 [0.39, 0.79], P < 0.01; 0.60 [0.37, 0.96], P < 0.05, 
      respectively) conferred a significant protective effect for lupus nephritis. DR3 
      and DR15 (OR, 2.00 [1.49, 2.70], P < 0.05; 1.60 [1.21, 2.12], P < 0.001, 
      respectively) were at a high risk of developing lupus nephritis. HLA-DR8, DR9 and 
      DR14 (OR, 1.47 [0.9, 2.33], P > 0.05; 0.90 [0.64, 1.27], P > 0.05; 0.61 [0.36, 
      1.03], P > 0.05, respectively) were not statistically significant between the 
      lupus nephritis and control groups. CONCLUSIONS: The HLA-DR4, DR11, DR14 alleles 
      might be protective factors for SLE and HLA-DR3, DR9, DR15 were potent risk 
      factors. In addition, HLA-DR4 and DR11 alleles might be protective factors for 
      lupus nephritis and DR3 and DR15 suggest a risk role. These results proved that 
      HLA-DR3, DR15, DR4 and DR11 might be identified as predictors for lupus nephritis 
      and SLE.
CI  - (c) 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Niu, Zhili
AU  - Niu Z
AD  - Department of Laboratory Science, Renmin Hospital of Wuhan University, Wuhan, Hu 
      Bei, China.
FAU - Zhang, Pingan
AU  - Zhang P
FAU - Tong, Yongqing
AU  - Tong Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20141226
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics/immunology
MH  - Humans
MH  - Lupus Erythematosus, Systemic/diagnosis/*genetics/immunology/prevention & control
MH  - Lupus Nephritis/diagnosis/*genetics/immunology/prevention & control
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Protective Factors
MH  - Risk Factors
OTO - NOTNLM
OT  - lupus nephritis
OT  - meta-analysis
OT  - susceptibility
OT  - systemic lupus erythematosus
EDAT- 2014/12/30 06:00
MHDA- 2015/12/24 06:00
CRDT- 2014/12/30 06:00
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/12/24 06:00 [medline]
AID - 10.1111/1756-185X.12528 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2015 Jan;18(1):17-28. doi: 10.1111/1756-185X.12528. Epub 2014 
      Dec 26.