PMID- 25546567
OWN - NLM
STAT- MEDLINE
DCOM- 20151113
LR  - 20181202
IS  - 1532-950X (Electronic)
IS  - 0161-3499 (Linking)
VI  - 44
IP  - 1
DP  - 2015 Jan
TI  - Extrahepatic biliary atresia in a 4-week-old Pug.
PG  - 35-40
LID - 10.1111/j.1532-950X.2014.12210.x [doi]
AB  - OBJECTIVE: To report diagnosis and surgical therapy of extrahepatic biliary 
      atresia in a dog. STUDY DESIGN: Clinical report. ANIMAL: Dog (n = 1). METHODS: A 
      4-week-old female intact Pug presented with acholic feces, lethargy, and poor 
      weight gain. On the basis of the stool color and abdominal ultrasonography 
      findings, extrahepatic biliary atresia was suspected. Intraoperatively, no major 
      duodenal papilla was identified and cholecystoduodenostomy was performed. 
      RESULTS: One day postoperatively the stool color was considered normal. On 
      ultrasonographic examinations up to 6 months after surgery, the gall bladder 
      remained small and the stoma was functional. Serum biochemical profile after 10 
      months had a mild increase in alanine-aminotransferase (149 U/L; reference 
      interval [RI], 0-85 U/L) whereas alkaline phosphatase and glutamate dehydrogenase 
      were within normal limits. At 15 months, clinical examination was normal and 
      blood ammonia concentration was within normal limits (43 micromol/L; RI: <100 micromol/L) 
      but bile acid concentrations were still markedly elevated (fasting, 95 micromol/L 
      [RI: <20 micromol/L] to postprandial, 127 micromol/L [RI: <35 micromol/L]). CONCLUSIONS: 
      Ultrasonography and stool color can be helpful noninvasive diagnostic evidence in 
      extrahepatic biliary atresia. Surgical correction with cholecystoduodenostomy 
      with a good clinical outcome is possible even in very young dogs. Long-term 
      prognosis in dogs with extrahepatic biliary atresia is unknown.
CI  - (c) Copyright 2014 by The American College of Veterinary Surgeons.
FAU - Thiel, Cetina
AU  - Thiel C
AD  - Department of Veterinary Clinical Sciences, Clinic for Small Animals, Surgery, 
      Justus-Liebig-University Giessen, Giessen, Germany.
FAU - Steinbach, Sarah
AU  - Steinbach S
FAU - Schmidt, Martin
AU  - Schmidt M
FAU - Amort, Kerstin
AU  - Amort K
FAU - Zahn, Nanette
AU  - Zahn N
FAU - Kramer, Martin
AU  - Kramer M
FAU - Moritz, Andreas
AU  - Moritz A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140603
PL  - United States
TA  - Vet Surg
JT  - Veterinary surgery : VS
JID - 8113214
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bile Ducts, Extrahepatic/*abnormalities
MH  - Biliary Atresia/surgery/*veterinary
MH  - Dog Diseases/blood/diagnostic imaging/*surgery
MH  - Dogs
MH  - Female
MH  - Prognosis
MH  - Ultrasonography
EDAT- 2014/12/30 06:00
MHDA- 2015/11/14 06:00
CRDT- 2014/12/30 06:00
PHST- 2013/03/01 00:00 [received]
PHST- 2014/04/01 00:00 [accepted]
PHST- 2014/12/30 06:00 [entrez]
PHST- 2014/12/30 06:00 [pubmed]
PHST- 2015/11/14 06:00 [medline]
AID - 10.1111/j.1532-950X.2014.12210.x [doi]
PST - ppublish
SO  - Vet Surg. 2015 Jan;44(1):35-40. doi: 10.1111/j.1532-950X.2014.12210.x. Epub 2014 
      Jun 3.