PMID- 25548481
OWN - NLM
STAT- MEDLINE
DCOM- 20150910
LR  - 20231213
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 20
IP  - 47
DP  - 2014 Dec 21
TI  - Dendritic cells in hepatitis C virus infection: key players in the IFNL3-genotype 
      response.
PG  - 17830-8
LID - 10.3748/wjg.v20.i47.17830 [doi]
AB  - Recently, single nucleotide polymorphisms, in the vicinity of the interferon 
      lambda 3 (IFNL3) gene have been identified as the strongest predictor of 
      spontaneous and treatment induced clearance of hepatitis C virus (HCV) infection. 
      Since then, increasing evidence has implicated the innate immune response in 
      mediating the IFNL3 genotype effect. Dendritic cells (DCs) are key to the host 
      immune response in HCV infection and their vital role in the IFNL3 genotype 
      effect is emerging. Reports have identified subclasses of DCs, particularly 
      myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in 
      the setting of HCV infection. Given the complexities of dendritic cell biology 
      and the conflicting current available data, this review aims to summarize what is 
      currently known regarding the role of dendritic cells in HCV infection and to 
      place it into context of what is know about lambda interferons and dendritic 
      cells in general.
FAU - O'Connor, Kate S
AU  - O'Connor KS
AD  - Kate S O'Connor, David Booth, Institute for Immunology and Allergy Research, 
      Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia.
FAU - George, Jacob
AU  - George J
AD  - Kate S O'Connor, David Booth, Institute for Immunology and Allergy Research, 
      Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia.
FAU - Booth, David
AU  - Booth D
AD  - Kate S O'Connor, David Booth, Institute for Immunology and Allergy Research, 
      Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia.
FAU - Ahlenstiel, Golo
AU  - Ahlenstiel G
AD  - Kate S O'Connor, David Booth, Institute for Immunology and Allergy Research, 
      Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (interferon-lambda, human)
RN  - 0 (Interleukins)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/metabolism/virology
MH  - Genotype
MH  - Hepacivirus/*immunology/metabolism/pathogenicity
MH  - Hepatitis C/diagnosis/*genetics/*immunology/metabolism/virology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Immunity, Innate/*genetics
MH  - Interferons
MH  - Interleukins/*genetics/*immunology/metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Signal Transduction
PMC - PMC4273133
OTO - NOTNLM
OT  - Dendritic cells
OT  - Hepatitis C virus
OT  - Innate immunity
OT  - Interferon lambda 3
OT  - Myeloid dendritic cells
OT  - Plasmacytoid dendritic cells
EDAT- 2014/12/31 06:00
MHDA- 2015/09/12 06:00
PMCR- 2014/12/21
CRDT- 2014/12/31 06:00
PHST- 2014/06/12 00:00 [received]
PHST- 2014/07/14 00:00 [revised]
PHST- 2014/07/24 00:00 [accepted]
PHST- 2014/12/31 06:00 [entrez]
PHST- 2014/12/31 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
PHST- 2014/12/21 00:00 [pmc-release]
AID - 10.3748/wjg.v20.i47.17830 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2014 Dec 21;20(47):17830-8. doi: 
      10.3748/wjg.v20.i47.17830.