PMID- 25548835
OWN - NLM
STAT- MEDLINE
DCOM- 20160602
LR  - 20150901
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 26
IP  - 7
DP  - 2015
TI  - Use of allogeneic stem cell transplantation for moderate-severe Glanzmann 
      thrombasthenia.
PG  - 702-4
LID - 10.3109/09537104.2014.987225 [doi]
AB  - Glanzmann thrombasthenia (GT) is a rare, autosomal recessive coagulopathy 
      characterized by either qualitative or quantitative abnormalities of the membrane 
      glycoprotein alphaIIbbeta3 complex leading to bleeding tendencies, ranging from purpura 
      to life-threatening hemorrhage. Although patients can be managed with supportive 
      measures including platelet transfusions, complications such as alloimmunization 
      are possible. Allogeneic stem cell transplantation (ASCT) can be indicated in 
      severe cases of GT. We report the case of an eight-month-old girl diagnosed with 
      moderate-severe GT, who was successfully treated with a reduced-intensity, human 
      leukocyte antigen (HLA)-identical ASCT.
FAU - Walz, Amy
AU  - Walz A
AD  - a Department of Hematology/Oncology/Transplantation , Ann & Robert H. Lurie 
      Children's Hospital , Chicago , IL , USA .
FAU - Lenzen, Alicia
AU  - Lenzen A
FAU - Curtis, Brian
AU  - Curtis B
FAU - Canner, Jason
AU  - Canner J
FAU - Schneiderman, Jennifer
AU  - Schneiderman J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20141230
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Blood Platelets/immunology/metabolism
MH  - Female
MH  - HLA Antigens/genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects/methods
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Severity of Illness Index
MH  - Siblings
MH  - Thrombasthenia/diagnosis/*therapy
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Glanzmann thrombasthenia
OT  - pediatric hematology/oncology
OT  - platelet disorders
OT  - stem cell transplant
EDAT- 2014/12/31 06:00
MHDA- 2016/06/03 06:00
CRDT- 2014/12/31 06:00
PHST- 2014/12/31 06:00 [entrez]
PHST- 2014/12/31 06:00 [pubmed]
PHST- 2016/06/03 06:00 [medline]
AID - 10.3109/09537104.2014.987225 [doi]
PST - ppublish
SO  - Platelets. 2015;26(7):702-4. doi: 10.3109/09537104.2014.987225. Epub 2014 Dec 30.