PMID- 25550113
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20150121
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 84
IP  - 2
DP  - 2015 Feb
TI  - Does modulation of spinal N-methyl-D-aspartic acid receptor by pre-activation 
      accelerate the development of morphine tolerance?
PG  - 91-3
LID - S0306-9877(14)00456-3 [pii]
LID - 10.1016/j.mehy.2014.12.012 [doi]
AB  - Repeated morphine administration usually leads to a number of neuroadaptive 
      processes, including tolerance and sensitization. However, research has shown 
      that the induction and maintenance of central sensitization is dependent on 
      N-methyl-d-aspartic acid receptor (NMDAR) activation. Chronic morphine exposure 
      has been shown to result in spinal sensitization and activation of spinal NMDARs. 
      Chronic morphine treatment and the activation of spinal NMDARs may be synergistic 
      and form a closed loop that may worsen the development of morphine analgesic 
      tolerance and spinal sensitization. Inhibition of NMDARs with an antagonist could 
      effectively alleviate the development of morphine analgesic tolerance. So, what 
      is the effect of modulating spinal NMDAR activation with exogenous agonists or 
      neuropathic input on the development of morphine-induced analgesic tolerance? Our 
      hypothesis is that chronic morphine treatment may worsen the already activation 
      of spinal NMDARs and spinal sensitization after agonist application or 
      neuropathic input to shorten the process of morphine-induced analgesic tolerance.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Xu, Tao
AU  - Xu T
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China.
FAU - Zhong, Wenhui
AU  - Zhong W
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China.
FAU - Ma, Xiaqing
AU  - Ma X
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China.
FAU - Zhao, Daqiang
AU  - Zhao D
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China.
FAU - Jiang, Wei
AU  - Jiang W
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China. Electronic address: 
      jiangw@sjtu.edu.cn.
FAU - Zhang, Xiaoli
AU  - Zhang X
AD  - Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai 
      Sixth People's Hospital, Shanghai 200233, China. Electronic address: 
      balor@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141220
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Drug Tolerance/*physiology
MH  - Humans
MH  - Models, Neurological
MH  - *Morphine
MH  - N-Methylaspartate/pharmacology
MH  - Neuralgia/*metabolism
MH  - Neurons/*metabolism
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Spinal Nerve Roots/*cytology
EDAT- 2015/01/01 06:00
MHDA- 2015/09/26 06:00
CRDT- 2015/01/01 06:00
PHST- 2014/10/27 00:00 [received]
PHST- 2014/11/25 00:00 [revised]
PHST- 2014/12/14 00:00 [accepted]
PHST- 2015/01/01 06:00 [entrez]
PHST- 2015/01/01 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - S0306-9877(14)00456-3 [pii]
AID - 10.1016/j.mehy.2014.12.012 [doi]
PST - ppublish
SO  - Med Hypotheses. 2015 Feb;84(2):91-3. doi: 10.1016/j.mehy.2014.12.012. Epub 2014 
      Dec 20.