PMID- 25550889
OWN - NLM
STAT- MEDLINE
DCOM- 20150922
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 11
DP  - 2014
TI  - Function and subsets of dendritic cells and natural killer cells were decreased 
      in gastric cancer.
PG  - 8304-11
AB  - Dendritic cells (DCs) and natural killer (NK) cells initiate specific immune 
      responses against tumor cells. The aim of the present study was to determine the 
      cytotoxicity and the subsets of the DC and NK cells and the cytokines level of DC 
      and NK cells from cancer tissue and peripheral blood in the gastric cancer 
      patients. Cytotoxicity of DC and NK was determined using the Cytotox 
      non-radioactive assay. The cytotoxic activity of DC or NK isolated from cancer 
      tissue and peripheral blood was attenuated in gastric cancer patients. CD11c, 
      CD80, CD83, CD16, CD57 and CD69 were decreased in the cancer tissue and 
      peripheral blood in the gastric cancer patients. CD86, CCR7 and CD59 were no 
      significance in the cancer tissue and peripheral blood from gastric cancer 
      patients. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, T-bet and IL-15Rbeta 
      levels were decreased in DC and NK from the gastric cancer tissue and peripheral 
      blood in the gastric cancer patients. IL-15 and IL-15Ralpha level were no 
      significance in DC and NK in the gastric cancer tissue and peripheral blood in 
      the gastric cancer patients. These results indicate that the cytotoxic activity 
      and subsets and cytokines of DC and NK cells in the cancer tissue and peripheral 
      blood in the gastric cancer patients were decreased. The decrease of subsets 
      content and cytokines of DC and NK may contribute to a decrease in the function 
      of DC and NK in the tissue and peripheral blood in the gastric cancer patients.
FAU - Chen, Jianping
AU  - Chen J
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Soochow 
      University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Soochow 
      University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
FAU - Jiang, Jingting
AU  - Jiang J
AD  - Department of Tumor Biological Treatment, The Third Affiliated Hospital of 
      Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, 
      China.
FAU - Zhuang, Yun
AU  - Zhuang Y
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Soochow 
      University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
FAU - He, Wei
AU  - He W
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Soochow 
      University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141015
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Blotting, Western
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/cytology/*immunology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunophenotyping
MH  - Killer Cells, Natural/cytology/*immunology
MH  - Lymphocyte Subsets/immunology
MH  - Stomach Neoplasms/*immunology
PMC - PMC4270606
OTO - NOTNLM
OT  - Dendritic cell
OT  - cytokine
OT  - cytotoxicity
OT  - natural killer cell
EDAT- 2015/01/01 06:00
MHDA- 2015/09/24 06:00
PMCR- 2014/10/15
CRDT- 2015/01/01 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/10/18 00:00 [accepted]
PHST- 2015/01/01 06:00 [entrez]
PHST- 2015/01/01 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
PHST- 2014/10/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Oct 15;7(11):8304-11. eCollection 2014.