PMID- 25552567 OWN - NLM STAT- MEDLINE DCOM- 20160226 LR - 20181202 IS - 1749-5024 (Electronic) IS - 1749-5016 (Print) IS - 1749-5016 (Linking) VI - 10 IP - 8 DP - 2015 Aug TI - Medial prefrontal cortex reacts to unfairness if this damages the self: a tDCS study. PG - 1054-60 LID - 10.1093/scan/nsu154 [doi] AB - Neural correlates of unfairness perception depend on who is the target of the unfair treatment. These previous findings suggest that the activation of medial prefrontal cortex (MPFC) is related to unfairness perception only when the subject of the measurement is also the person affected by the unfair treatment. We aim at demonstrating the specificity of MPFC involvement using transcranial direct current stimulation (tDCS), a technique that induces cortical excitability changes in the targeted region. We use a modified version of the Ultimatum Game, in which responders play both for themselves (myself-MS condition) and on behalf of an unknown third-party (TP condition), where they respond to unfairness without being the target of it. We find that the application of cathodal tDCS over MPFC decreases the probability of rejecting unfair offers in MS, but not in TP; conversely, the same stimulation increases the probability of rejecting fair offers in TP, but not in MS. We confirm the hypothesis that MPFC is specifically related to processing unfairness when the self is involved, and discuss possible explanations for the opposite effect of the stimulation in TP. CI - (c) The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com. FAU - Civai, Claudia AU - Civai C AD - Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands c.civai@donders.ru.nl. FAU - Miniussi, Carlo AU - Miniussi C AD - Neuroscience Section, Department of Clinical and Experimental Sciences, University of Brescia, Italy Cognitive Neuroscience Section, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia Italy, and. FAU - Rumiati, Raffaella I AU - Rumiati RI AD - Neuroscience Area, SISSA, Trieste, Italy. LA - eng PT - Journal Article DEP - 20141230 PL - England TA - Soc Cogn Affect Neurosci JT - Social cognitive and affective neuroscience JID - 101288795 SB - IM MH - Adolescent MH - Adult MH - Ego MH - Electrodes MH - Female MH - Games, Experimental MH - Humans MH - *Morals MH - Prefrontal Cortex/*physiology MH - Psychomotor Performance/physiology MH - *Social Perception MH - *Transcranial Direct Current Stimulation MH - Young Adult PMC - PMC4526475 OTO - NOTNLM OT - MPFC OT - Ultimatum Game OT - non-invasive brain stimulation OT - self-other OT - unfairness EDAT- 2015/01/02 06:00 MHDA- 2016/02/27 06:00 PMCR- 2016/08/01 CRDT- 2015/01/02 06:00 PHST- 2014/07/14 00:00 [received] PHST- 2014/12/24 00:00 [accepted] PHST- 2015/01/02 06:00 [entrez] PHST- 2015/01/02 06:00 [pubmed] PHST- 2016/02/27 06:00 [medline] PHST- 2016/08/01 00:00 [pmc-release] AID - nsu154 [pii] AID - 10.1093/scan/nsu154 [doi] PST - ppublish SO - Soc Cogn Affect Neurosci. 2015 Aug;10(8):1054-60. doi: 10.1093/scan/nsu154. Epub 2014 Dec 30.