PMID- 25553289
OWN - NLM
STAT- MEDLINE
DCOM- 20161114
LR  - 20181113
IS  - 2234-3814 (Electronic)
IS  - 2234-3806 (Print)
IS  - 2234-3806 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Jan
TI  - Inflammatory cytokines and their prognostic ability in cases of major burn 
      injury.
PG  - 105-10
LID - 10.3343/alm.2015.35.1.105 [doi]
AB  - BACKGROUND: Major burn injuries induce inflammatory responses and changes in the 
      levels of various cytokines. This study was conducted to assess early changes in 
      the serum levels of inflammatory cytokines after burn injury, identify cytokines 
      associated with mortality, and characterize correlations among cytokines. 
      METHODS: Blood samples of 67 burn patients were collected on days 1 and 3 after 
      burn injury, and the concentrations of 27 cytokines were measured using the 
      Bio-Plex Suspension Array System (Bio-Rad Laboratories, USA). Blood samples of 25 
      healthy subjects were used as controls. We analyzed statistical differences in 
      the concentrations of each cytokine between the control and patient groups, 
      between day 1 and day 3, and between survival and nonsurvival groups. 
      Correlations among 27 cytokines were analyzed. RESULTS: Median concentrations of 
      granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage 
      colony-stimulating factor (GM-CSF), interleukin 1 receptor antagonist (IL-1RA), 
      interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), interleukin 
      15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory 
      protein 1beta (MIP-1beta), and vascular endothelial growth factor (VEGF) were 
      significantly higher in burn patients than in controls. IL-1RA, IL-6, and MCP-1 
      levels were significantly higher in the nonsurvival group than in the survival 
      group on day 1 after burn injury. Correlation analysis of 27 cytokines showed 
      different relationships with one another. Stronger correlations among interferon 
      gamma (IFN-gamma), IL-2, IL-4, IL-7, IL-12p70, and IL-17 were found. CONCLUSIONS: IL-1RA, 
      IL-6, and MCP-1 may be used as prognostic indicators of mortality in burn 
      patients and the increase in cytokine concentrations is induced by interactions 
      within a complex network of cytokine-related pathways.
FAU - Hur, Jun
AU  - Hur J
AD  - Department of Burn Surgery, Hallym University Hangang Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Yang, Hyeong Tae
AU  - Yang HT
AD  - Department of Burn Surgery, Hallym University Hangang Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Chun, Wook
AU  - Chun W
AD  - Department of Burn Surgery, Hallym University Hangang Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Kim, Jong-Hyun
AU  - Kim JH
AD  - Department of Burn Surgery, Hallym University Hangang Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Shin, Seon-Hee
AU  - Shin SH
AD  - Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym 
      University College of Medicine, Hwaseong, Korea.
FAU - Kang, Hee Jung
AU  - Kang HJ
AD  - Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, 
      Hallym University College of Medicine, Anyang, Korea.
FAU - Kim, Hyun Soo
AU  - Kim HS
AD  - Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart 
      Hospital, Hallym University College of Medicine, Hwaseong, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141208
PL  - Korea (South)
TA  - Ann Lab Med
JT  - Annals of laboratory medicine
JID - 101571172
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Burns/*blood/mortality/*pathology
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Survival Rate
MH  - Young Adult
PMC - PMC4272939
OTO - NOTNLM
OT  - Burn
OT  - Cytokine
OT  - Inflammation
OT  - Mortality
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2015/01/02 06:00
MHDA- 2016/11/15 06:00
PMCR- 2015/01/01
CRDT- 2015/01/02 06:00
PHST- 2014/06/11 00:00 [received]
PHST- 2014/07/07 00:00 [revised]
PHST- 2014/11/21 00:00 [accepted]
PHST- 2015/01/02 06:00 [entrez]
PHST- 2015/01/02 06:00 [pubmed]
PHST- 2016/11/15 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3343/alm.2015.35.1.105 [doi]
PST - ppublish
SO  - Ann Lab Med. 2015 Jan;35(1):105-10. doi: 10.3343/alm.2015.35.1.105. Epub 2014 Dec 
      8.