PMID- 25553392
OWN - NLM
STAT- MEDLINE
DCOM- 20151109
LR  - 20220311
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 32
DP  - 2015 Feb
TI  - Defining dendritic cells.
PG  - 13-20
LID - S0952-7915(14)00148-4 [pii]
LID - 10.1016/j.coi.2014.11.001 [doi]
AB  - Dendritic cells (DCs) are versatile controllers of the immune system, best known 
      for their potent ability to initiate adaptive immunity. Traditionally, DCs have 
      been defined on the basis of cell morphology, expression of specific markers and 
      select functional attributes such as the ability to migrate to T cell areas of 
      secondary lymphoid organs and activate T lymphocytes. However, such properties 
      are not qualitative and often change in conditions of inflammation or infection. 
      Phenotypic-based and function-based definitions can therefore lead to 
      difficulties in cell identification. Here we review other approaches to try and 
      solve questions of DC lineage attribution with an emphasis on recent insights 
      arising from our increased understanding of DC ontogeny and differentiation.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Schraml, Barbara U
AU  - Schraml BU
AD  - Institute for Medical Microbiology, Immunology and Hygiene, Technische 
      Universitat Munchen, Trogerstr. 30, 81675 Munich, Germany. Electronic address: 
      barbara.schraml@tum.de.
FAU - Reis e Sousa, Caetano
AU  - Reis e Sousa C
AD  - Immunobiology Laboratory, Cancer Research UK, London Research Institute, 
      Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3LY, 
      United Kingdom. Electronic address: caetano@cancer.org.uk.
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141203
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics/immunology
MH  - Cell Lineage/genetics/immunology
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Gene Expression Profiling
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Transcription Factors/genetics/metabolism
MH  - Transcriptome
EDAT- 2015/01/02 06:00
MHDA- 2015/11/10 06:00
CRDT- 2015/01/02 06:00
PHST- 2014/10/24 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/11/17 00:00 [accepted]
PHST- 2015/01/02 06:00 [entrez]
PHST- 2015/01/02 06:00 [pubmed]
PHST- 2015/11/10 06:00 [medline]
AID - S0952-7915(14)00148-4 [pii]
AID - 10.1016/j.coi.2014.11.001 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2015 Feb;32:13-20. doi: 10.1016/j.coi.2014.11.001. Epub 2014 
      Dec 3.