PMID- 25553393
OWN - NLM
STAT- MEDLINE
DCOM- 20151109
LR  - 20220409
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 32
DP  - 2015 Feb
TI  - C-type lectins in immunity: recent developments.
PG  - 21-7
LID - S0952-7915(14)00150-2 [pii]
LID - 10.1016/j.coi.2014.12.002 [doi]
AB  - C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which 
      recognise a diverse range of ligands, and are defined by the presence of at least 
      one C-type lectin-like domain (CTLD). Of particular interest are the single 
      extracellular CTLD-containing receptors of the 'Dectin-1' and 'Dectin-2' 
      clusters, which associate with signalling adaptors or possess integral 
      intracellular signalling domains. These CLRs have traditionally been associated 
      with the recognition of fungi, but recent discoveries have revealed diverse and 
      unexpected functions. In this review, we describe their newly identified roles in 
      anti-microbial host defence, homeostasis, autoimmunity, allergy and their 
      functions in the recognition and response to dead and cancerous cells.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Dambuza, Ivy M
AU  - Dambuza IM
AD  - Aberdeen Fungal Group, Division of Applied Medicine, Immunity, Infection and 
      Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, 
      Aberdeen AB25 2ZD, UK.
FAU - Brown, Gordon D
AU  - Brown GD
AD  - Aberdeen Fungal Group, Division of Applied Medicine, Immunity, Infection and 
      Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, 
      Aberdeen AB25 2ZD, UK. Electronic address: gordon.brown@abdn.ac.uk.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 097377/WT_/Wellcome Trust/United Kingdom
GR  - 102705/WT_/Wellcome Trust/United Kingdom
GR  - 102705/Z/13/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141229
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Mitogen)
SB  - IM
MH  - Animals
MH  - Autoimmunity
MH  - Fungi/immunology
MH  - Homeostasis
MH  - Humans
MH  - Hypersensitivity/immunology/metabolism
MH  - *Immunity
MH  - Immunomodulation
MH  - Lectins, C-Type/*metabolism
MH  - Mycobacterium/immunology
MH  - Mycobacterium Infections/immunology/metabolism
MH  - Mycoses/immunology/metabolism
MH  - Neoplasms/immunology/metabolism
MH  - Receptors, Mitogen/chemistry/metabolism
MH  - Signal Transduction
PMC - PMC4589735
EDAT- 2015/01/02 06:00
MHDA- 2015/11/10 06:00
PMCR- 2015/02/01
CRDT- 2015/01/02 06:00
PHST- 2014/11/05 00:00 [received]
PHST- 2014/12/03 00:00 [revised]
PHST- 2014/12/10 00:00 [accepted]
PHST- 2015/01/02 06:00 [entrez]
PHST- 2015/01/02 06:00 [pubmed]
PHST- 2015/11/10 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - S0952-7915(14)00150-2 [pii]
AID - 10.1016/j.coi.2014.12.002 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2015 Feb;32:21-7. doi: 10.1016/j.coi.2014.12.002. Epub 2014 
      Dec 29.