PMID- 25553404 OWN - NLM STAT- MEDLINE DCOM- 20150825 LR - 20230921 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 174 DP - 2015 Mar 15 TI - BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. PG - 432-40 LID - S0165-0327(14)00754-X [pii] LID - 10.1016/j.jad.2014.11.044 [doi] AB - BACKGROUND: Peripheral brain-derived neurotrophic factor (BDNF) is decreased in acute major depressive disorder (MDD) and bipolar disorder (BD) and recovered after treatment. Here we validated on a meta-analytical level whether BDNF restores differentially according to treatment response and whose measurements could be used as a biomarker, plasma or serum. METHODS: Using strict inclusion criteria, we compared BDNF in healthy controls and patients with MDD (38 studies, n=6619), and BD (17 studies, n=1447). Pre- and post-treatment BDNF levels were meta-analyzed according to treatment response in patients from 21 MDD studies (n=735) and 7 BD studies (n=88). Serum and plasma subgroups were analyzed, publication bias was assessed and heterogeneity was investigated. RESULTS: Serum and plasma BDNF were decreased in acute MDD and BD, and did not differ in euthymia in comparison with control subjects. Antidepressive treatment increased serum BDNF levels in MDD in responders (Cohen׳s d (d)=1.27, p=4.4E-07) and remitters (d=0.89, p=0.01), significantly more than in non-responders (d=0.11, p=0.69). For plasma BDNF in MDD and for BD, the evidence was insufficient for a meta-analysis. Although no significant difference was found between serum and plasma ES, variance of plasma ES was higher. LIMITATIONS: Between-study heterogeneity was explained only partially; signs of publication bias in serum studies. CONCLUSION: Serum BDNF might be regarded as a biomarker for the successful treatment of MDD. Serum measurements seem more reliable than plasma ones. Further research should focus on defining optimal time points for BDNF measurements and increase evidence for the usage of BDNF as a predictive biomarker in BD. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Polyakova, Maryna AU - Polyakova M AD - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic for Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Germany. Electronic address: polyakova@cbs.mpg.de. FAU - Stuke, Katharina AU - Stuke K AD - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. FAU - Schuemberg, Katharina AU - Schuemberg K AD - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. FAU - Mueller, Karsten AU - Mueller K AD - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. FAU - Schoenknecht, Peter AU - Schoenknecht P AD - Clinic for Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Germany. FAU - Schroeter, Matthias L AU - Schroeter ML AD - Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Germany. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20141129 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Antidepressive Agents) RN - 0 (Biomarkers, Pharmacological) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Antidepressive Agents/therapeutic use MH - Biomarkers, Pharmacological/blood MH - Bipolar Disorder/*blood/drug therapy MH - Brain-Derived Neurotrophic Factor/*blood/drug effects MH - Cyclothymic Disorder/drug therapy MH - Depressive Disorder, Major/*blood/drug therapy MH - Humans MH - Plasma/metabolism MH - Serum/metabolism OTO - NOTNLM OT - BDNF OT - Biomarker OT - Bipolar OT - Brain-derived neurotrophic factor OT - Major depression OT - Response EDAT- 2015/01/02 06:00 MHDA- 2015/08/26 06:00 CRDT- 2015/01/02 06:00 PHST- 2014/07/28 00:00 [received] PHST- 2014/11/20 00:00 [revised] PHST- 2014/11/23 00:00 [accepted] PHST- 2015/01/02 06:00 [entrez] PHST- 2015/01/02 06:00 [pubmed] PHST- 2015/08/26 06:00 [medline] AID - S0165-0327(14)00754-X [pii] AID - 10.1016/j.jad.2014.11.044 [doi] PST - ppublish SO - J Affect Disord. 2015 Mar 15;174:432-40. doi: 10.1016/j.jad.2014.11.044. Epub 2014 Nov 29.