PMID- 25553795
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20161026
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 388
DP  - 2015
TI  - New insights on the signaling and function of the high-affinity receptor for IgE.
PG  - 63-90
LID - 10.1007/978-3-319-13725-4_4 [doi]
AB  - Clustering of the high-affinity receptor for immunoglobulin E (FcepsilonRI) through the 
      interaction of receptor-bound immunoglobulin E (IgE) antibodies with their 
      cognate antigen is required to couple IgE antibody production to cellular 
      responses and physiological consequences. IgE-induced responses through FcepsilonRI are 
      well known to defend the host against certain infectious agents and to lead to 
      unwanted allergic responses to normally innocuous substances. However, the 
      cellular and/or physiological response of individuals that produce IgE antibodies 
      may be markedly different and such antibodies (even to the same antigenic 
      epitope) can differ in their antigen-binding affinity. How affinity variation in 
      the interaction of FcepsilonRI-bound IgE antibodies with antigen is interpreted into 
      cellular responses and how the local environment may influence these responses is 
      of interest. In this chapter, we focus on recent advances that begin to unravel 
      how FcepsilonRI distinguishes differences in the affinity of IgE-antigen interactions 
      and how such discrimination along with surrounding environmental stimuli can 
      shape the (patho) physiological response.
FAU - Suzuki, Ryo
AU  - Suzuki R
AD  - Molecular Immunology Section, Laboratory of Molecular Immunogenetics, National 
      Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes 
      of Health, Bethesda, MD, 20892, USA.
FAU - Scheffel, Jorg
AU  - Scheffel J
FAU - Rivera, Juan
AU  - Rivera J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, IgE)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Receptors, G-Protein-Coupled/physiology
MH  - Receptors, IgE/*physiology
MH  - Toll-Like Receptors/physiology
EDAT- 2015/01/03 06:00
MHDA- 2015/04/10 06:00
CRDT- 2015/01/03 06:00
PHST- 2015/01/03 06:00 [entrez]
PHST- 2015/01/03 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1007/978-3-319-13725-4_4 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2015;388:63-90. doi: 10.1007/978-3-319-13725-4_4.