PMID- 25553887
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20150623
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 11
IP  - 3
DP  - 2015 May-Jun
TI  - Acid suppression medications are associated with suboptimal weight loss after 
      laparoscopic Roux-en-Y gastric bypass in patients older than 40 years.
PG  - 585-90
LID - S1550-7289(14)00369-4 [pii]
LID - 10.1016/j.soard.2014.09.027 [doi]
AB  - BACKGROUND: Bariatric surgery, including laparoscopic Roux-en-Y gastric bypass 
      (LRYGB), achieves the greatest long-term weight loss in severe obesity. 
      Approximately 50%-60% of severely obese patients have gastroesophageal reflux 
      disease, and a substantial proportion is taking a proton pump inhibitor (PPI) or 
      histamine-2 blocker (H2 B) at the time of LRYGB. The objective of this study was 
      to explore the association of PPI/H2 B use before LRYGB with suboptimal percent 
      weight loss (PWL) after LRYGB. METHODS: This was a cohort study of 472 
      consecutive patients who underwent LRYGB at a single center from 2004-2011. 
      Suboptimal PWL was defined as<14% at 2 months,<25% at 6 months, and<30% at 12 
      months. Because of effect modification by age, stratified analyses (by median age 
      of 40 yr) were performed. All models were adjusted for appropriate covariates, 
      including obesity-associated co-morbidities. RESULTS: For patients aged </=40 
      years, PPI/H2 B use leading up to LRYGB was not associated with suboptimal PWL at 
      2 months (P = .86), 6 months (P = .47), or 12 months (P = .66). However, for 
      patients aged>40 years, PPI/H2 B use leading up to LRYGB was associated with a 
      nonsignificant increase in suboptimal PWL at 2 months (odds ratio [OR] 2.23; P = 
      .08) and significant increases in suboptimal PWL at 6 months (OR 7.23; P = .002) 
      and 12 months (OR 11.1; P = .02). Results were independent of GERD. CONCLUSIONS: 
      Mechanisms for the poorer weight loss in patients aged>40 years who were using a 
      PPI/H2 B just before LRYGB should be explored.
CI  - Copyright (c) 2015 American Society for Bariatric Surgery. Published by Elsevier 
      Inc. All rights reserved.
FAU - Ward, Emily K
AU  - Ward EK
AD  - Division of Gastroenterology & Hepatology, University of Colorado Denver, Aurora, 
      Colorado.
FAU - Jensen-Otsu, Elsbeth
AU  - Jensen-Otsu E
AD  - Department of Medicine, University of Colorado Denver, Aurora, Colorado.
FAU - Schoen, Jonathon A
AU  - Schoen JA
AD  - Division of Gastrointestinal, Tumor and Endocrine Surgery, University of Colorado 
      Denver, Aurora, Colorado.
FAU - Rothchild, Kevin
AU  - Rothchild K
AD  - Division of Gastrointestinal, Tumor and Endocrine Surgery, University of Colorado 
      Denver, Aurora, Colorado.
FAU - Mitchell, Breana
AU  - Mitchell B
AD  - Division of Gastrointestinal, Tumor and Endocrine Surgery, University of Colorado 
      Denver, Aurora, Colorado.
FAU - Austin, Gregory L
AU  - Austin GL
AD  - Division of Gastroenterology & Hepatology, University of Colorado Denver, Aurora, 
      Colorado. Electronic address: Gregory.austin@ucdenver.edu.
LA  - eng
PT  - Journal Article
DEP - 20141007
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Surg Obes Relat Dis. 2015 May-Jun;11(3):590-1. PMID: 25457161
CIN - Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1187-9. PMID: 26645493
CIN - Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1190-1. PMID: 26645494
MH  - Adult
MH  - Body Mass Index
MH  - Female
MH  - Follow-Up Studies
MH  - Gastric Acid/*metabolism
MH  - Gastric Acidity Determination
MH  - Gastric Bypass/*methods
MH  - Gastroesophageal Reflux/complications/*drug therapy/metabolism
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Obesity, Morbid/complications/*surgery
MH  - Postoperative Care/*methods
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Time Factors
MH  - Weight Loss
OTO - NOTNLM
OT  - Gastroesophageal reflux disease
OT  - Histamine 2 blocker
OT  - Proton pump inhibitor
OT  - Roux-en-Y gastric bypass
OT  - Weight loss
EDAT- 2015/01/03 06:00
MHDA- 2016/04/20 06:00
CRDT- 2015/01/03 06:00
PHST- 2014/05/14 00:00 [received]
PHST- 2014/09/04 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2015/01/03 06:00 [entrez]
PHST- 2015/01/03 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - S1550-7289(14)00369-4 [pii]
AID - 10.1016/j.soard.2014.09.027 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2015 May-Jun;11(3):585-90. doi: 10.1016/j.soard.2014.09.027. 
      Epub 2014 Oct 7.