PMID- 25554494
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20150302
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 3
DP  - 2015 Mar
TI  - BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by 
      attenuating p38 MAPK phosphorylation.
PG  - 1303-9
LID - S0197-4580(14)00787-8 [pii]
LID - 10.1016/j.neurobiolaging.2014.11.016 [doi]
AB  - The oligomeric form of the amyloid peptide Abeta(1-42) is capable of perturbing 
      synaptic plasticity in different brain areas. Here, we evaluated the protective 
      role of brain-derived neurotrophic factor (BDNF) in beta amyloid (Abeta)-dependent 
      impairment of long-term potentiation in entorhinal cortex (EC) slices. We found 
      that BDNF (1 ng/mL) supplied by perfusion was able to rescue long-term 
      potentiation in Abeta(1-42)-treated slices; BDNF protection was mediated by TrkB 
      receptor as assessed by using the tyrosine kinase inhibitor K252a (200 nM). We 
      also investigated the function of endogenous BDNF using a soluble form of TrkB 
      receptor (TrkB IgG). Incubation of slices with TrkB IgG (1 mug/mL) increased the 
      EC vulnerability to Abeta. Finally, we investigated the effect of BDNF on the cell 
      stress-kinase p38 mitogen-activated protein kinase (MAPK) in primary cortical 
      cell cultures exposed to Abeta(1-42). We found that Abeta induces p38 MAPK 
      phosphorylation, although pretreatment with BDNF prevented Abeta-dependent p38 MAPK 
      phosphorylation. This result was confirmed by an immunoassay in tissue extracts 
      from EC slices collected after electrophysiology.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Criscuolo, Chiara
AU  - Criscuolo C
AD  - Neuroscience Institute, Italian National Research Council, Pisa, Italy; 
      Department of Applied Clinical Sciences and Biotechnology, University of 
      L'Aquila, Coppito, L'Aquila, Italy.
FAU - Fabiani, Carlotta
AU  - Fabiani C
AD  - Neuroscience Institute, Italian National Research Council, Pisa, Italy.
FAU - Bonadonna, Camilla
AU  - Bonadonna C
AD  - Neuroscience Institute, Italian National Research Council, Pisa, Italy.
FAU - Origlia, Nicola
AU  - Origlia N
AD  - Neuroscience Institute, Italian National Research Council, Pisa, Italy.
FAU - Domenici, Luciano
AU  - Domenici L
AD  - Neuroscience Institute, Italian National Research Council, Pisa, Italy; 
      Department of Applied Clinical Sciences and Biotechnology, University of 
      L'Aquila, Coppito, L'Aquila, Italy. Electronic address: domenici@in.cnr.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141202
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Alzheimer Disease/etiology/prevention & control
MH  - Amyloid beta-Peptides/*adverse effects
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Entorhinal Cortex/*physiology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*drug effects
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/drug effects
MH  - *Neuroprotective Agents
MH  - Peptide Fragments/*adverse effects
MH  - Phosphorylation/drug effects
MH  - Receptor, trkB/physiology
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Neurodegeneration
OT  - Neuroprotection
OT  - Synaptic plasticity
EDAT- 2015/01/03 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/01/03 06:00
PHST- 2014/01/22 00:00 [received]
PHST- 2014/10/24 00:00 [revised]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2015/01/03 06:00 [entrez]
PHST- 2015/01/03 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - S0197-4580(14)00787-8 [pii]
AID - 10.1016/j.neurobiolaging.2014.11.016 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Mar;36(3):1303-9. doi: 
      10.1016/j.neurobiolaging.2014.11.016. Epub 2014 Dec 2.