PMID- 25554536
OWN - NLM
STAT- MEDLINE
DCOM- 20150407
LR  - 20220317
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 115
IP  - 4
DP  - 2015 Feb 15
TI  - Effect of statin therapy on incident type 2 diabetes mellitus in patients with 
      clinically manifest vascular disease.
PG  - 441-6
LID - S0002-9149(14)02162-6 [pii]
LID - 10.1016/j.amjcard.2014.11.021 [doi]
AB  - Several trials and cohort studies have shown an increased incidence of type 2 
      diabetes mellitus (T2DM) in patients using statins. Whether this only applies to 
      patients at already high risk for the development of T2DM or for all patients is 
      still a matter of debate. In the present prospective cohort study of 4,645 
      patients with established vascular disease without DM at baseline, 3,057 patients 
      used statins at baseline, of whom 1,608 used intensive statin therapy, defined as 
      statin therapy theoretically lowering low-density lipoprotein cholesterol with 
      >/=40%. Cox proportional hazards models were used to estimate the risk of incident 
      T2DM with (intensive) statin therapy. Statin therapy was associated with 
      increased risk of incident T2DM (hazard ratio 1.63; 95% confidence interval 1.15 
      to 2.32) when adjusted for age, gender, body mass index, plasma high-density 
      lipoprotein cholesterol, and plasma triglyceride levels. Intensive statin therapy 
      tended to be related to a higher risk of T2DM compared with moderate statin 
      therapy (hazard ratio 1.22; 95% confidence interval 0.92 to 1.61, adjusted for 
      age, gender, body mass index, plasma high-density lipoprotein cholesterol, and 
      plasma triglyceride levels). The increase in risk was regardless of the number of 
      metabolic syndrome characteristics or insulin resistance but was particularly 
      present in patients with low baseline glucose levels (<5.6 mmol/L; p for 
      interaction 2.9 x 10(-7)). In conclusion, statin use increases the risk of 
      incident T2DM in patients with clinically manifest vascular disease. The increase 
      in risk was independent of the number of metabolic syndrome criteria and was even 
      more pronounced in patients with low baseline glucose levels.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - van de Woestijne, Anton P
AU  - van de Woestijne AP
AD  - Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - van der Graaf, Yolanda
AU  - van der Graaf Y
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, The Netherlands.
FAU - Westerink, Jan
AU  - Westerink J
AD  - Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Nathoe, Hendrik M
AU  - Nathoe HM
AD  - Division of Heart and Lungs, Department of Cardiology, University Medical Center 
      Utrecht, Utrecht, The Netherlands.
FAU - Visseren, Frank L J
AU  - Visseren FL
AD  - Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The 
      Netherlands. Electronic address: F.L.J.visseren@umcutrecht.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141129
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Body Mass Index
MH  - Cholesterol, LDL/*blood/drug effects
MH  - Diabetes Mellitus, Type 2/chemically induced/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use
MH  - Incidence
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Vascular Diseases/blood/*prevention & control
EDAT- 2015/01/03 06:00
MHDA- 2015/04/08 06:00
CRDT- 2015/01/03 06:00
PHST- 2014/08/29 00:00 [received]
PHST- 2014/11/25 00:00 [revised]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2015/01/03 06:00 [entrez]
PHST- 2015/01/03 06:00 [pubmed]
PHST- 2015/04/08 06:00 [medline]
AID - S0002-9149(14)02162-6 [pii]
AID - 10.1016/j.amjcard.2014.11.021 [doi]
PST - ppublish
SO  - Am J Cardiol. 2015 Feb 15;115(4):441-6. doi: 10.1016/j.amjcard.2014.11.021. Epub 
      2014 Nov 29.