PMID- 25555946
OWN - NLM
STAT- MEDLINE
DCOM- 20150309
LR  - 20150103
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 99
IP  - 1
DP  - 2015 Jan
TI  - Initial clinical experience with the Symphony heart assist system.
PG  - 298-301
LID - S0003-4975(14)01969-9 [pii]
LID - 10.1016/j.athoracsur.2014.07.094 [doi]
AB  - PURPOSE: Current cardiac assist devices provide full support, require a major 
      operation, and function asynchronously to the native heart. In contrast, we 
      developed a novel circulatory support device that provides synchronous partial 
      support and can be placed with a minor operation. We report the first clinical 
      implantation with the Symphony device (Abiomed, Danvers, MA). DESCRIPTION: 
      Patients with advanced heart failure despite optimal therapy who had exhausted 
      all options were evaluated. A 64-year-old man with ischemic cardiomyopathy 
      underwent implantation of the Symphony device in the right infraclavicular fossa. 
      EVALUATION: After initiating device support, the cardiac index increased from 1.7 
      to 2.5 L/min/m(2), pulmonary capillary wedge pressure decreased from 26 to 13 mm 
      Hg, right atrial pressure decreased from 12 to 7 mm Hg, creatinine level 
      decreased from 2.3 to 1.5 mg/dL, and New York Heart Association (NYHA) class 
      improved from IIIB to II. CONCLUSIONS: Placement of the Symphony device resulted 
      in improvements in hemodynamics and functional status. Further clinical data will 
      help define the role for this approach of partial synchronous support through a 
      less invasive operation in patients with advanced heart failure.
CI  - Copyright (c) 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All 
      rights reserved.
FAU - Cecere, Renzo
AU  - Cecere R
AD  - Division of Cardiac Surgery, Department of Surgery, McGill University, Montreal, 
      Quebec, Canada. Electronic address: renzo.cecere@muhc.mcgill.ca.
FAU - Dowling, Robert D
AU  - Dowling RD
AD  - DCI, Inc, Louisville, KY.
FAU - Giannetti, Nadia
AU  - Giannetti N
AD  - Division of Cardiology, Department of Medicine, McGill University, Montreal, 
      Quebec, Canada.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Heart Failure/*surgery
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*surgery
MH  - Prosthesis Design
EDAT- 2015/01/06 06:00
MHDA- 2015/03/10 06:00
CRDT- 2015/01/04 06:00
PHST- 2014/01/27 00:00 [received]
PHST- 2014/05/16 00:00 [revised]
PHST- 2014/07/09 00:00 [accepted]
PHST- 2015/01/04 06:00 [entrez]
PHST- 2015/01/06 06:00 [pubmed]
PHST- 2015/03/10 06:00 [medline]
AID - S0003-4975(14)01969-9 [pii]
AID - 10.1016/j.athoracsur.2014.07.094 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2015 Jan;99(1):298-301. doi: 10.1016/j.athoracsur.2014.07.094.