PMID- 25556115
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20160225
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 122
IP  - 4
DP  - 2015 Apr
TI  - Optic nerve head changes after short-term intraocular pressure elevation in acute 
      primary angle-closure suspects.
PG  - 730-7
LID - S0161-6420(14)01054-9 [pii]
LID - 10.1016/j.ophtha.2014.11.008 [doi]
AB  - PURPOSE: To investigate changes in the optic nerve head morphology after acute 
      intraocular pressure (IOP) elevation during a dark room prone provocative test 
      (DRPPT). DESIGN: Prospective cohort study. PARTICIPANTS: Acute primary 
      angle-closure (APAC) suspects underwent DRPPT. METHODS: Study participants stayed 
      in a dark room for 2 hours with the forehead placed on a desk. At baseline and 
      within 5 minutes after DRPPT, tonometry and enhanced depth imaging by 
      spectral-domain optical coherence tomography (SD OCT) were performed. MAIN 
      OUTCOME MEASURES: Changes in 3-dimensional optic nerve head topography. RESULTS: 
      The study included 114 eyes of 65 participants with a mean age of 58.3+/-8.7 years 
      and a mean IOP elevation of 10.1+/-10.9 mmHg during DRPPT. When all eyes were 
      included, the mean value of most optic disc parameters did not change 
      significantly, except for a decrease in the temporal minimal rim width (P = 
      0.005). By including only eyes with an IOP increase greater than 15 mmHg, the 
      mean value of cup width (P = 0.001) and cup depth (P = 0.002) increased, whereas 
      the lamina cribrosa (LC) thickness (P = 0.035), temporal minimal rim width (P = 
      0.001), and nasal minimal rim width (P < 0.001) decreased. The LC depth and 
      Bruch's membrane opening (BMO) did not differ between the baseline and the end of 
      DRPPT. An IOP increase was significantly associated with widening (P < 0.001; r = 
      0.46) and deepening (P < 0.001; r = 0.52) of the optic cup, thinning of the LC (P 
      = 0.003; r = -0.35), temporal minimal rim width (P < 0.001; r = -0.34), and nasal 
      minimal rim width (P < 0.001; r = -0.35). CONCLUSIONS: Angle-closure suspect eyes 
      showed a widening and deepening of the optic cup, decrease in neuroretinal rim 
      width, and thinning of the LC after a darkness-induced IOP increase of >15 mmHg. 
      The diameter of the BMO and position of the anterior LC surface remained 
      unchanged. This suggests that a short-term IOP increase leads to a condensation 
      of neuroretinal rim, prelaminar tissue, and LC, without major changes in the 
      optic disc size and position of the anterior LC surface.
CI  - Copyright (c) 2015 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Jiang, Ran
AU  - Jiang R
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China.
FAU - Xu, Liang
AU  - Xu L
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China.
FAU - Liu, Xue
AU  - Liu X
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China.
FAU - Chen, Jian Dong
AU  - Chen JD
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China.
FAU - Jonas, Jost B
AU  - Jonas JB
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China; Department of Ophthalmology, Medical Faculty 
      Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, 
      Germany.
FAU - Wang, Ya Xing
AU  - Wang YX
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China. Electronic address: yaxingw@gmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141231
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
CIN - Ophthalmology. 2015 Dec;122(12):e72-3. PMID: 26592678
CIN - Ophthalmology. 2015 Dec;122(12):e73. PMID: 26592680
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biometry
MH  - Cohort Studies
MH  - Dark Adaptation
MH  - Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Glaucoma, Angle-Closure/*physiopathology
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*physiopathology
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
EDAT- 2015/01/04 06:00
MHDA- 2015/06/13 06:00
CRDT- 2015/01/04 06:00
PHST- 2014/08/16 00:00 [received]
PHST- 2014/10/23 00:00 [revised]
PHST- 2014/11/06 00:00 [accepted]
PHST- 2015/01/04 06:00 [entrez]
PHST- 2015/01/04 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - S0161-6420(14)01054-9 [pii]
AID - 10.1016/j.ophtha.2014.11.008 [doi]
PST - ppublish
SO  - Ophthalmology. 2015 Apr;122(4):730-7. doi: 10.1016/j.ophtha.2014.11.008. Epub 
      2014 Dec 31.