PMID- 25556757
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20181202
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 45
IP  - 2
DP  - 2015 Feb
TI  - Worse outcome in women with STEMI: a systematic review of prognostic studies.
PG  - 226-35
LID - 10.1111/eci.12399 [doi]
AB  - BACKGROUND: Treatment of ST elevation myocardial infarction (STEMI) has improved 
      enormously since the introduction of primary percutaneous coronary intervention 
      (pPCI). It remains unclear whether differences in survival between women and men 
      treated with pPCI exist and whether these potential differences can be explained 
      by gender or by differences in baseline- or procedural characteristics. Therefore 
      we systematically reviewed the available evidence. MATERIALS AND METHODS: On 10 
      May 2013 PubMed, Embase and Cochrane were searched for studies comprising 
      original data on STEMI patients treated with pPCI. A separate gender analysis 
      including > 100 women was a requirement. Data were extracted and pooled whenever 
      possible. RESULTS: 21 studies were included from 2001 to 2013 comprising 47.439 
      men and 16.927 women. Women were older, had more diabetes (women 24%, men 15%) 
      and hypertension (women 58%, men 45%), and were less current smokers (women 30%, 
      men 54%). The procedural characteristics were comparable except for a longer 
      symptom-to-balloon time (women 266 min, men 240 min) and less use of GP IIb/IIIa 
      inhibitors in women (women 51%, men 57%). Crude short- and long-term mortality 
      was higher in women. Although we could not pool adjusted mortality proportions 
      due to heterogeneity, generally the difference in mortality disappeared after 
      adjustment for baseline- and procedural characteristics. CONCLUSION: Mortality is 
      higher in women with STEMI and can be explained by their unfavourable risk 
      profile and longer symptom-to-balloon time.
CI  - (c) 2014 Stichting European Society for Clinical Investigation Journal Foundation.
FAU - van der Meer, Manon G
AU  - van der Meer MG
AD  - Department of Cardiology, University Medical Centre Utrecht, Utrecht, the 
      Netherlands.
FAU - Nathoe, Hendrik M
AU  - Nathoe HM
FAU - van der Graaf, Yolanda
AU  - van der Graaf Y
FAU - Doevendans, Pieter A
AU  - Doevendans PA
FAU - Appelman, Yolande
AU  - Appelman Y
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
SB  - IM
MH  - Aged
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*mortality/therapy
MH  - Percutaneous Coronary Intervention/*mortality
MH  - Prognosis
MH  - Risk Factors
MH  - Sex Factors
OTO - NOTNLM
OT  - Gender
OT  - ST elevation myocardial infarction
OT  - primary PCI
EDAT- 2015/01/06 06:00
MHDA- 2015/10/22 06:00
CRDT- 2015/01/06 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/12/29 00:00 [accepted]
PHST- 2015/01/06 06:00 [entrez]
PHST- 2015/01/06 06:00 [pubmed]
PHST- 2015/10/22 06:00 [medline]
AID - 10.1111/eci.12399 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2015 Feb;45(2):226-35. doi: 10.1111/eci.12399.