PMID- 25557063 OWN - NLM STAT- MEDLINE DCOM- 20150729 LR - 20201220 IS - 1872-7123 (Electronic) IS - 0165-1781 (Print) IS - 0165-1781 (Linking) VI - 231 IP - 2 DP - 2015 Feb 28 TI - Clinical high risk and first episode schizophrenia: auditory event-related potentials. PG - 126-33 LID - S0925-4927(14)00309-6 [pii] LID - 10.1016/j.pscychresns.2014.11.012 [doi] AB - The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership. CI - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved. FAU - del Re, Elisabetta C AU - del Re EC AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: elisabetta_delre@hms.harvard.edu. FAU - Spencer, Kevin M AU - Spencer KM AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. FAU - Oribe, Naoya AU - Oribe N AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Mesholam-Gately, Raquelle I AU - Mesholam-Gately RI AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA. FAU - Goldstein, Jill AU - Goldstein J AD - Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Brigham and Women׳s Hospital, Connors Center for Women׳s Health and Gender Biology, Boston, MA, USA; Departments of Psychiatry and Medicine, Harvard Medical School, Boston, MA, USA. FAU - Shenton, Martha E AU - Shenton ME AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Department of Radiology, Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, USA. FAU - Petryshen, Tracey AU - Petryshen T AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. FAU - McCarley, Robert W AU - McCarley RW AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. FAU - Niznikiewicz, Margaret A AU - Niznikiewicz MA AD - VA Boston Healthcare System, Brockton, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. LA - eng GR - R01 MH040799/MH/NIMH NIH HHS/United States GR - K05 MH070047/MH/NIMH NIH HHS/United States GR - R01MH50747/MH/NIMH NIH HHS/United States GR - R01MH40799/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - I01 CX000154/CX/CSRD VA/United States GR - R01MH052807/MH/NIMH NIH HHS/United States GR - K05MH070047/MH/NIMH NIH HHS/United States GR - UL1 RR025758/RR/NCRR NIH HHS/United States GR - P50MH080272/MH/NIMH NIH HHS/United States GR - R01 MH052807/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20141129 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Adult MH - Attention/*physiology MH - Electroencephalography/*methods MH - Event-Related Potentials, P300/physiology MH - Evoked Potentials, Auditory/*physiology MH - Female MH - Humans MH - Male MH - Psychomotor Performance/*physiology MH - Psychotic Disorders/psychology MH - Risk MH - Schizophrenia/*physiopathology MH - Young Adult PMC - PMC4314407 MID - NIHMS645938 OTO - NOTNLM OT - N100 OT - P200 OT - P3a OT - P3b EDAT- 2015/01/06 06:00 MHDA- 2015/07/30 06:00 PMCR- 2016/02/28 CRDT- 2015/01/06 06:00 PHST- 2014/05/21 00:00 [received] PHST- 2014/11/07 00:00 [revised] PHST- 2014/11/19 00:00 [accepted] PHST- 2015/01/06 06:00 [entrez] PHST- 2015/01/06 06:00 [pubmed] PHST- 2015/07/30 06:00 [medline] PHST- 2016/02/28 00:00 [pmc-release] AID - S0925-4927(14)00309-6 [pii] AID - 10.1016/j.pscychresns.2014.11.012 [doi] PST - ppublish SO - Psychiatry Res. 2015 Feb 28;231(2):126-33. doi: 10.1016/j.pscychresns.2014.11.012. Epub 2014 Nov 29.