PMID- 25557532
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 84
IP  - 2
DP  - 2016 Feb
TI  - Prevalence of parathyroid carcinoma in 348 patients with multiple endocrine 
      neoplasia type 1 - case report and review of the literature.
PG  - 244-249
LID - 10.1111/cen.12714 [doi]
AB  - OBJECTIVE: To report the prevalence of parathyroid carcinoma (PC) in patients 
      with multiple endocrine neoplasia type 1 (MEN1) and review of the literature. 
      BACKGROUND: Primary hyperparathyroidism (PHP) is the most common manifestation of 
      MEN1. The occurrence of PC in patients with MEN1 is rare and the literature 
      regarding the clinical manifestations - including the prevalence of the disease - 
      is scarce. CONTEXT: Single tertiary care centre experience from 1977 to 2013. 
      DESIGN: Electronic search of the medical records to identify a cohort of patients 
      with MEN1. Literature review based on current case reports. PATIENTS: Single case 
      of PC in a cohort of 348 patients with MEN1. Ten cases of PC in patients with 
      MEN1 reported in the literature. MEASUREMENT: Clinical features of PC in patients 
      with MEN1. RESULTS: The prevalence of PC in 348 patients with MEN1 was found to 
      be 0.28% (95% CI, 0-1.4%). Based on the current published cases of PC in patients 
      with MEN1, 54.5% were women, mean age at diagnosis was 48.3 years, and the serum 
      PTH concentrations at least four times the upper limit of the reference range in 
      73% of the cases. CONCLUSION: PC in patients with MEN 1 is rare with a prevalence 
      of 0.28%, and the clinical features are similar to PC in patients without MEN1.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Singh Ospina, Naykky
AU  - Singh Ospina N
AD  - Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of 
      Internal Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Sebo, Thomas J
AU  - Sebo TJ
AD  - Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
FAU - Thompson, Geoffrey B
AU  - Thompson GB
AD  - Section of Endocrine Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Clarke, Bart L
AU  - Clarke BL
AD  - Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of 
      Internal Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Young, William F Jr
AU  - Young WF Jr
AD  - Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of 
      Internal Medicine, Mayo Clinic, Rochester, MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20150212
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
EDAT- 2015/01/06 06:00
MHDA- 2015/01/06 06:01
CRDT- 2015/01/06 06:00
PHST- 2014/10/20 00:00 [received]
PHST- 2014/11/25 00:00 [revised]
PHST- 2014/12/05 00:00 [revised]
PHST- 2014/12/27 00:00 [accepted]
PHST- 2015/01/06 06:00 [pubmed]
PHST- 2015/01/06 06:01 [medline]
PHST- 2015/01/06 06:00 [entrez]
AID - 10.1111/cen.12714 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2016 Feb;84(2):244-249. doi: 10.1111/cen.12714. Epub 2015 
      Feb 12.