PMID- 25558558
OWN - NLM
STAT- MEDLINE
DCOM- 20150205
LR  - 20150106
IS  - 1300-0144 (Print)
IS  - 1300-0144 (Linking)
VI  - 44
IP  - 1
DP  - 2014
TI  - Prognostic value of neutrophil/lymphocyte ratio in patients with pulmonary 
      embolism.
PG  - 50-5
AB  - AIM: Preliminary evidence suggests that inflammation plays a role in the 
      development and prognosis of pulmonary embolism (PE). We used the 
      neutrophil/lymphocyte ratio (NLR) as a measure of systemic inflammation and 
      investigated its association with PE. MATERIALS AND METHODS: A total of 266 
      patients who were diagnosed with PE and a control group of 124 age- and 
      sex-matched healthy subjects were included in this study. We further classified 
      the PE patients into 2 groups: those who survived and those who died in the first 
      30 days. Baseline NLR was measured by dividing neutrophil count to lymphocyte 
      count and was compared between the groups. RESULTS: Median NLR was significantly 
      higher among patients with PE compared to the healthy control group (3.9 
      (interquartile range (IQR): 5.0) vs. 1.9 (IQR: 0.6), P < 0.001). Of the 266 
      patients with PE, 16 (6%) died within 1 month. Median NLR was significantly 
      higher among PE patients who died compared to those who survived, as well (3.7 
      (IQR: 4.3) vs. 9.0 (IQR: 7.9), P < 0.001). The optimal cut-off values, 
      sensitivities, and specificities of NLR for predicting PE and in-hospital 
      mortality of PE were >2.565 and >5.465, 70.3% and 75.0%, and 92.7% and 67.6%, 
      respectively. Multiple logistic regression analysis showed that NLR values of 
      >5.465 could define those patients with a mortal clinical course independently 
      (odds ratio: 13.446, 95% confidence interval: 3.141-57.566, P < 0.001).
FAU - Cavus, Umut Yucel
AU  - Cavus UY
AD  - Department of Emergency Medicine, Diskapi Yildirim Beyazit Research Hospital, 
      Ankara, Turkey. acildrumut@yahoo.com
FAU - Yildirim, Sinan
AU  - Yildirim S
FAU - Sonmez, Ertan
AU  - Sonmez E
FAU - Ertan, Cagatay
AU  - Ertan C
FAU - Ozeke, Ozcan
AU  - Ozeke O
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis
MH  - Humans
MH  - Inflammation/complications
MH  - Leukocyte Count
MH  - Logistic Models
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - *Neutrophils
MH  - Prognosis
MH  - Pulmonary Embolism/*immunology/mortality
MH  - Retrospective Studies
EDAT- 2015/01/07 06:00
MHDA- 2015/02/06 06:00
CRDT- 2015/01/07 06:00
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/02/06 06:00 [medline]
PST - ppublish
SO  - Turk J Med Sci. 2014;44(1):50-5.