PMID- 25559211
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20150814
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 48
IP  - 3
DP  - 2015 Sep
TI  - Neuron-specific enolase correlates to laboratory markers of haemolysis in 
      patients on long-term circulatory support.
PG  - 416-20; discussion 420
LID - 10.1093/ejcts/ezu513 [doi]
AB  - OBJECTIVES: Neuron-specific enolase (NSE) is used as a diagnostic tool in 
      neuropathies, cerebral diseases or traumata and for some tumours. Furthermore, it 
      is also expressed by erythrocytes and platelets and has been linked to haemolysis 
      ex vivo as a laboratory issue. Chronic haemolysis is frequently associated with 
      mechanical circulatory support by ventricular assist device (VAD) or total 
      artificial heart (TAH). Therefore, we compared NSE with indicators of haemolysis 
      in VAD and TAH patients. METHODS: We included 599 data sets of 97 patients who 
      underwent VAD or TAH implantation. NSE, haptoglobin (HAPT), haemopexin (HPX), 
      free haemoglobin (frHB), lactate dehydrogenase activity (LDH), platelet counts 
      and total bilirubin (TBIL) in plasma were analysed. Further, all major cerebral 
      events were assessed. RESULTS: NSE correlated to frHB (rs = 0.553) and to LDH (rs 
      = 0.695). An inverse correlation was found with HAPT (rs = -0.484) and HPX (rs = 
      -0.398). Thirty-two patients suffered neurological events. Within the time frame 
      of 1 day before to 4 days after a neurological event, correlations of NSE to HAPT 
      (rs = -0.540) and HPX (rs = -0.611) in negative and to frHB (rs = 0.757), LDH (rs 
      = 0.862) and TBIL (rs = 0.549) in positive direction were established (all P < 
      0.05). Furthermore, haemolysis was graded into three groups for severe, moderate 
      or no or only slight haemolysis. NSE values differed correspondingly between 
      these groups (P < 0.001). CONCLUSION: NSE correlates to laboratory parameters 
      indicative of haemolysis in VAD and TAH patients. Our data suggest an influence 
      of intravascular haemolysis on NSE. Therefore, the parameter should be used with 
      caution when it is used to assess cerebral damage.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the European 
      Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Geisen, Ulrich
AU  - Geisen U
AD  - Institute of Clinical Chemistry and Laboratory Medicine, Medical Center, 
      University of Freiburg, Freiburg, Germany.
FAU - Benk, Christoph
AU  - Benk C
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Beyersdorf, Friedhelm
AU  - Beyersdorf F
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Klemm, Rolf
AU  - Klemm R
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Trummer, Georg
AU  - Trummer G
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Ozbek, Beatrice
AU  - Ozbek B
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Kern, Franziska
AU  - Kern F
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Heilmann, Claudia
AU  - Heilmann C
AD  - Department of Cardiovascular Surgery, Heart Center, University of Freiburg, 
      Freiburg, Germany claudia.heilmann@universitaets-herzzentrum.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150105
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Haptoglobins)
RN  - 0 (Hemoglobins)
RN  - 9013-71-2 (Hemopexin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Bilirubin/blood
MH  - Haptoglobins/analysis
MH  - Heart, Artificial/*adverse effects
MH  - Hemoglobins/analysis
MH  - Hemolysis/*physiology
MH  - Hemopexin/analysis
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Phosphopyruvate Hydratase/*blood
MH  - Platelet Count
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cerebrovascular injury
OT  - Haemolysis
OT  - Neuron-specific enolase
OT  - Ventricular assist device
EDAT- 2015/01/07 06:00
MHDA- 2016/06/04 06:00
CRDT- 2015/01/07 06:00
PHST- 2014/09/12 00:00 [received]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
AID - ezu513 [pii]
AID - 10.1093/ejcts/ezu513 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2015 Sep;48(3):416-20; discussion 420. doi: 
      10.1093/ejcts/ezu513. Epub 2015 Jan 5.