PMID- 25559237
OWN - NLM
STAT- MEDLINE
DCOM- 20160729
LR  - 20181202
IS  - 2047-6310 (Electronic)
IS  - 2047-6302 (Linking)
VI  - 10
IP  - 6
DP  - 2015 Dec
TI  - Reduced retinal nerve fibre layer thickness in children with severe obesity.
PG  - 448-53
LID - 10.1111/ijpo.12005 [doi]
AB  - BACKGROUND: Some optic nerve diseases are silent and insidious. Recently, reduced 
      thickness of retinal nerve fibre layer (RNFL) has been associated with increasing 
      body mass index in adults. OBJECTIVES: To investigate the association of 
      childhood obesity with RNFL measured by optical coherence tomography imaging. 
      METHODS: Ninety-seven children aged 5-14 years classified according to standard 
      deviation score of body mass index (SDS-BMI) were included. Parameters of 
      metabolic risk, adipocytokines (leptin, adiponectin) and interleukin-6 were 
      analyzed. All subjects underwent a comprehensive ophthalmologic examination with 
      direct ophthalmoscopy. Evaluation of RNFL with optical coherence tomography of 
      the head of the nerve was performed. RESULTS: RNFL thickness on the average and 
      inferior, superior and nasal quadrants were decreased in severely obese children 
      (SDS-BMI > 4) with respect to the other groups. However, no statistically 
      significant association was found between the different groups of children and 
      RNFL thickness in the temporal quadrant. There was a significant inverse 
      correlation of RNFL thickness with adiposity indices (P = 0.016), leptin 
      (P = 0.029) and interleukin-6 (P = 0.030) in overweight and obese children. 
      CONCLUSIONS: These findings suggest that adiposity and obesity-related 
      inflammatory factors may be associated with the loss of retinal ganglion cells in 
      children.
CI  - (c) 2014 World Obesity.
FAU - Pacheco-Cervera, J
AU  - Pacheco-Cervera J
AD  - Department of Ophthalmology, Doctor Peset University Hospital, Valencia, Spain.
FAU - Codoner-Franch, P
AU  - Codoner-Franch P
AD  - Department of Pediatrics, Doctor Peset University Hospital, Valencia, Spain.
AD  - Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 
      Valencia, Spain.
FAU - Simo-Jorda, R
AU  - Simo-Jorda R
AD  - Department of Pediatrics, Doctor Peset University Hospital, Valencia, Spain.
FAU - Pons-Vazquez, S
AU  - Pons-Vazquez S
AD  - Department of Ophthalmology, Doctor Peset University Hospital, Valencia, Spain.
FAU - Galbis-Estrada, C
AU  - Galbis-Estrada C
AD  - Ophthalmic Research Unit Santiago Grisolia, Faculty of Medicine, University of 
      Valencia, Valencia, Spain.
FAU - Pinazo-Duran, M D
AU  - Pinazo-Duran MD
AD  - Department of Ophthalmology, Doctor Peset University Hospital, Valencia, Spain.
AD  - Ophthalmic Research Unit Santiago Grisolia, Faculty of Medicine, University of 
      Valencia, Valencia, Spain.
AD  - Surgery-Ophthalmology Department, Faculty of Medicine, University of Valencia, 
      Valencia, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150105
PL  - England
TA  - Pediatr Obes
JT  - Pediatric obesity
JID - 101572033
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
SB  - IM
MH  - Adiponectin/blood
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Leptin/blood
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Obesity, Morbid/blood/complications/*pathology
MH  - Pediatric Obesity/blood/complications/*pathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - *Tomography, Optical Coherence
OTO - NOTNLM
OT  - Leptin
OT  - optical coherence tomography
OT  - paediatric obesity
OT  - retinal nerve fibre layer
EDAT- 2015/01/07 06:00
MHDA- 2016/07/30 06:00
CRDT- 2015/01/07 06:00
PHST- 2014/09/13 00:00 [received]
PHST- 2014/11/24 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2016/07/30 06:00 [medline]
AID - 10.1111/ijpo.12005 [doi]
PST - ppublish
SO  - Pediatr Obes. 2015 Dec;10(6):448-53. doi: 10.1111/ijpo.12005. Epub 2015 Jan 5.