PMID- 25559382
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20181113
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 21
DP  - 2015 Jan 6
TI  - The effects of oxytocin on cognitive defect caused by chronic restraint stress 
      applied to adolescent rats and on hippocampal VEGF and BDNF levels.
PG  - 69-75
LID - 10.12659/MSM.893159 [doi]
AB  - BACKGROUND: Because brain development continues during adolescence, the effects 
      of chronic stress on hippocampal changes that occur during that period are 
      permanent. Oxytocin, which is synthesized in the hypothalamus and has many 
      receptors in brain regions, including the hippocampus, may affect 
      learning-memory. This study aimed to investigate chronic restraint stress on 
      hippocampal functions, and hippocampal vascular endothelial growth factor (VEGF) 
      and brain-derived neurotrophic factor (BDNF) levels in adolescent male and female 
      rats and the role of oxytocin in these effects. MATERIAL/METHODS: Experimental 
      groups included control, stress+oxytocin, and stress+saline groups. Restraint 
      stress was applied to all the stress groups for 1 h/day, for 7 days. 
      Learning-memory tests were performed after the 7th day. RESULTS: In the 
      stress+oxytocin groups, the process of finding the platform was shorter than in 
      others groups. The stress+saline groups spent less time, whereas the 
      stress+oxytocin groups spent more time, on the target quadrant in the probe 
      trial. In the stress+oxytocin groups thigmotaxis time (indicating anxiety) 
      decreased, but VEGF and BDNF levels increased. A positive correlation was found 
      between VEGF and BDNF levels and the time spent within the target quadrant. 
      CONCLUSIONS: The results indicate that impaired hippocampal learning and memory 
      loss due to chronic restraint stress can be positively affected by intranasal 
      oxytocin.
FAU - Dayi, Ayfer
AU  - Dayi A
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Cetin, Ferihan
AU  - Cetin F
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Sisman, Ali Riza
AU  - Sisman AR
AD  - Department of Biochemistry, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Aksu, Ilkay
AU  - Aksu I
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Tas, Aysegul
AU  - Tas A
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Gonenc, Sevil
AU  - Gonenc S
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
FAU - Uysal, Nazan
AU  - Uysal N
AD  - Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150106
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, rat)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition Disorders/*drug therapy
MH  - Female
MH  - Hippocampus/drug effects/*metabolism
MH  - Hypothalamus/drug effects
MH  - Learning/drug effects
MH  - Male
MH  - Maze Learning
MH  - Memory/drug effects
MH  - Oxytocin/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Vascular Endothelial Growth Factor A/*metabolism
PMC - PMC4294596
EDAT- 2015/01/07 06:00
MHDA- 2015/10/28 06:00
PMCR- 2015/01/06
CRDT- 2015/01/07 06:00
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
PHST- 2015/01/06 00:00 [pmc-release]
AID - 893159 [pii]
AID - 10.12659/MSM.893159 [doi]
PST - epublish
SO  - Med Sci Monit. 2015 Jan 6;21:69-75. doi: 10.12659/MSM.893159.