PMID- 25559753
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20150317
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 47
IP  - 4
DP  - 2015 Apr
TI  - No differential effects of divergent isocaloric supplements on signaling for 
      muscle protein turnover during recovery from muscle-damaging eccentric exercise.
PG  - 767-78
LID - 10.1007/s00726-014-1907-8 [doi]
AB  - Unaccustomed high-intensity eccentric exercise (ECC) can provoke muscle damage 
      including several days of muscle force loss. Post-exercise dietary 
      supplementation may provide a strategy to accelerate rate of force regain by 
      affecting mechanisms related to muscle protein turnover. The aim of the current 
      study was to investigate if protein signaling mechanisms involved in muscle 
      protein turnover would be differentially affected by supplementation with either 
      whey protein hydrolysate and carbohydrate (WPH+CHO) versus isocaloric 
      carbohydrate (CHO) after muscle-damaging ECC. Twenty-four young healthy 
      participants received either WPH+CHO (n = 12) or CHO supplements (n = 12) during 
      post-exercise recovery from 150 maximal unilateral eccentric contractions. Prior 
      to, at 3 h and at 24, 48, 96 and/or 168 h post-exercise, muscle strength, muscle 
      soreness, and Akt-mTOR and FOXO signaling proteins, were measured in an ECC 
      exercising leg and in the contralateral non-exercise control leg (CON). After 
      ECC, muscle force decreased by 23-27 % at 24 h post-exercise, which was followed 
      by gradual, although not full recovery at 168 h post-exercise, with no 
      differences between supplement groups. Phosphorylation of mTOR, p70S6K and rpS6 
      increased and phosphorylation of FOXO1 and FOXO3 decreased in the ECC leg, with 
      no differences between supplement groups. Phosphorylation changes were also 
      observed for rpS6, FOXO1 and FOXO3a in the CON leg, suggesting occurrence of 
      remote tissue effects. In conclusion, divergent dietary supplementation types did 
      not produce differences in signaling for muscle turnover during recovery from 
      muscle-damaging exercise.
FAU - Rahbek, Stine Klejs
AU  - Rahbek SK
AD  - Section of Sport Science, Department of Public Health, Aarhus University, Dalgas 
      Avenue 4, Aarhus C, 8000, Aarhus, Denmark.
FAU - Farup, Jean
AU  - Farup J
FAU - de Paoli, Frank
AU  - de Paoli F
FAU - Vissing, Kristian
AU  - Vissing K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150106
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Muscle Proteins)
SB  - IM
MH  - Dietary Supplements/*analysis
MH  - Exercise
MH  - Humans
MH  - Male
MH  - Muscle Proteins/*metabolism
MH  - Muscle, Skeletal/*injuries/metabolism
MH  - Myalgia/etiology/*metabolism
MH  - Resistance Training/*adverse effects
MH  - Signal Transduction
MH  - Young Adult
EDAT- 2015/01/07 06:00
MHDA- 2016/01/15 06:00
CRDT- 2015/01/07 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2014/12/17 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
AID - 10.1007/s00726-014-1907-8 [doi]
PST - ppublish
SO  - Amino Acids. 2015 Apr;47(4):767-78. doi: 10.1007/s00726-014-1907-8. Epub 2015 Jan 
      6.