PMID- 25560818
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 19
IP  - 1
DP  - 2015 Jan
TI  - Exploratory analysis of dietary intake and brain iron accumulation detected using 
      magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936.
PG  - 64-9
LID - 10.1007/s12603-014-0523-3 [doi]
AB  - CONTEXT: Brain Iron Deposits (IDs) are associated with neurodegenerative diseases 
      and impaired cognitive function in later life, but their cause is unknown. Animal 
      studies have found evidence of relationships between dietary iron, calorie and 
      cholesterol intake and brain iron accumulation. OBJECTIVES: To investigate the 
      relationship between iron, calorie, and cholesterol intake, blood indicators of 
      iron status, and brain IDs in humans. DESIGN, SETTING AND PARTICIPANTS: Cohort of 
      1063 community-dwelling older individuals born in 1936 (mean age 72.7years, 
      SD=0.7) with dietary information, results from blood sample analyses and brain 
      imaging data contemporaneously in old age. MEASUREMENTS: Magnetic Resonance 
      Imaging was used to assess regional volumes of brain IDs in basal ganglia, 
      brainstem, white matter, thalamus, and cortex/border with the corticomedullary 
      junction, using a fully automatic assessment procedure followed by individual 
      checking/correction where necessary. Haemoglobin, red cell count, haematocrit, 
      mean cell volume, ferritin and transferrin were obtained from blood samples and 
      typical daily intake of iron, calories, and cholesterol were calculated from a 
      validated food-frequency questionnaire. RESULTS: Overall, 72.8% of the sample 
      that had valid MRI (n=676) had brain IDs. The median total volume of IDs was 
      40mm3, inter-quartile range (IQR)=196. Basal ganglia IDs (median=35, IQR=159.5 
      mm3), were found in 70.6% of the sample. IDs in the brainstem were found in 12.9% 
      of the sample, in the cortex in 1.9%, in the white matter in 6.1% and in the 
      thalamus in 1.0%. The median daily intake of calories was 1808.5kcal (IQR=738.5), 
      of cholesterol was 258.5mg (IQR=126.2) and of total iron was 11.7mg (IQR=5). 
      Iron, calorie or cholesterol intake were not directly associated with brain IDs. 
      However, caloric intake was associated with ferritin, an iron storage protein 
      (p=0.01). CONCLUSION: Our results suggest that overall caloric, iron and 
      cholesterol intake are not associated with IDs in brains of healthy older 
      individuals but caloric intake could be associated with iron storage. Further 
      work is required to corroborate our findings on other samples and investigate the 
      underlying mechanisms of brain iron accumulation.
FAU - Hernandez, M del C Valdes
AU  - Hernandez Mdel C
AD  - Dr. Maria C. Valdes Hernandez, Brain Research Imaging Centre, Department of 
      Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Crewe 
      Road, Edinburgh EH4 2XU, UK. Telephone: +44-131-537-3093, Fax: +44-131-332-5150, 
      E-mail: mvhernan@staffmail.ed.ac.uk.
FAU - Allan, J
AU  - Allan J
FAU - Glatz, A
AU  - Glatz A
FAU - Kyle, J
AU  - Kyle J
FAU - Corley, J
AU  - Corley J
FAU - Brett, C E
AU  - Brett CE
FAU - Maniega, S Munoz
AU  - Maniega SM
FAU - Royle, N A
AU  - Royle NA
FAU - Bastin, M E
AU  - Bastin ME
FAU - Starr, J M
AU  - Starr JM
FAU - Deary, I J
AU  - Deary IJ
FAU - Wardlaw, J M
AU  - Wardlaw JM
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
GR  - G0700704/MRC_/Medical Research Council/United Kingdom
GR  - G1001245/MRC_/Medical Research Council/United Kingdom
GR  - G0701120/MRC_/Medical Research Council/United Kingdom
GR  - MR/K026992/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Hemoglobins)
RN  - 0 (Iron, Dietary)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Aging/metabolism
MH  - Brain/anatomy & histology/*metabolism
MH  - Cholesterol/administration & dosage/metabolism
MH  - Cognition/physiology
MH  - Cohort Studies
MH  - Diet/*statistics & numerical data
MH  - Energy Intake
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Female
MH  - Ferritins/blood
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Iron, Dietary/administration & dosage/*analysis/*metabolism
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Neurodegenerative Diseases
MH  - *Neuroimaging
MH  - Surveys and Questionnaires
MH  - Transferrin/analysis
EDAT- 2015/01/07 06:00
MHDA- 2015/10/09 06:00
CRDT- 2015/01/07 06:00
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - S1279-7707(23)01433-1 [pii]
AID - 10.1007/s12603-014-0523-3 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2015 Jan;19(1):64-9. doi: 10.1007/s12603-014-0523-3.