PMID- 25561226
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20181202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Dec 30
TI  - Association between ADIPOQ +45T>G polymorphism and type 2 diabetes: a systematic 
      review and meta-analysis.
PG  - 704-23
LID - 10.3390/ijms16010704 [doi]
AB  - Recently, a number of studies have reported the association between the single 
      nucleotide polymorphisms (SNPs) +45 T>G polymorphism in the adiponectin (ADIPOQ) 
      gene and type 2 diabetes mellitus (T2DM) risk, though the results are 
      inconsistent. In order to obtain a more precise estimation of the relationship, a 
      meta-analysis was performed. In this current study, the Medline, Embase, Pubmed, 
      ISI Web of Knowledge, Ovid, Science Citation Index Expanded Database, Wanfang 
      Database, and China National Knowledge Infrastructure were searched for eligible 
      studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to 
      estimate the strength of association. Forty-five publications were included in 
      the final meta-analysis with 9986 T2DM patients and 16,222 controls for ADIPOQ 
      +45 T>G polymorphism according to our inclusion and exclusion criteria. The +45 
      T>G polymorphism was associated with an overall significantly increased risk of 
      T2DM (G vs. T: OR = 1.18, 95% CI = 1.06-1.32; The dominant model: OR = 1.18, 95% 
      CI = 1.03-1.33; The recessive model: OR = 1.47, 95% CI = 1.20-1.78; The 
      homozygous model: OR = 1.62, 95% CI = 1.25-2.09; Except the heterozygous model: 
      OR = 1.11, 95% CI = 0.98-1.24). Subgroup analysis revealed a significant 
      association between the +45 T>G polymorphism and T2D in an Asian population. 
      Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45 T>G 
      polymorphisms associated with a significantly increased risk of T2DM in the Asian 
      population.
FAU - Fan, Yaofu
AU  - Fan Y
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. fanyaofu2010@163.com.
FAU - Wang, Kun
AU  - Wang K
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. wangkun112011@163.com.
FAU - Xu, Shuhang
AU  - Xu S
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. xushuhang112011@163.com.
FAU - Chen, Guofang
AU  - Chen G
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. chenguofang112011@163.com.
FAU - Di, Hongjie
AU  - Di H
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. dihongjie112011@163.com.
FAU - Cao, Meng
AU  - Cao M
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. caomeng112011@163.com.
FAU - Liu, Chao
AU  - Liu C
AD  - Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of 
      Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 
      210028, China. liuchao@nfmcn.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20141230
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Alleles
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC4307270
EDAT- 2015/01/07 06:00
MHDA- 2015/09/15 06:00
PMCR- 2015/01/01
CRDT- 2015/01/07 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2014/12/18 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - ijms16010704 [pii]
AID - ijms-16-00704 [pii]
AID - 10.3390/ijms16010704 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Dec 30;16(1):704-23. doi: 10.3390/ijms16010704.